癫痫患者自由基代谢的变化及其与脑电图的关系  

The Change of Free Radicals Metabilsme in Epilepsy and the Relationship Between Free Radicals and EEG

作　　者：徐运[1] 蒋定国[1] 张国英 

机构地区：[1]南京医科大学附属医院神经科,扬州市人民医院脑电图室

出　　处：《临床实用神经疾病杂志》1994年第4期176-178,共3页

摘　　要：本文选择癫痫患者３０例，分别于发作期和缓解期作血浆总抗氧化能力（ＧＡＡ）、血浆谷胱甘肽（ＧＳＨ１）、血红蛋白谷胱甘肽（ＧＳＨ２）及血浆丙二醛（ＭＤＡ）的检测及脑电图检查。结果提示：发作期，ＭＤＡ明显高于正常。缓解期近于正常，ＭＤＡ升高者，ＥＥＧ多数异常，ＧＡＡ、ＧＳＨ的变化也具有显著意义。揭示自由基代谢参与癫痫的病理过程。In this paper, plasma general antioxidation ability(GAA), plasma GSH_1,Hb GSH_2 plasma MDA and EEG were measured in 30 cases with epilepsy in episode and intermitting period repectively. The results suggest that MDA in episode period is higher than that of controls and MDA in intermitting period is similar to controls. Most EEGs are abnormal in patients with high MDA in blood. The changes of GAA and GSH also are significnt remarkably. It indicates that free radicals take part in the pathological process of epilepsy.

关 键 词：自由基代谢 癫痫患者 丙二醛(MDA) 总抗氧化能力 谷胱甘肽 脑电图检查 血红蛋白 病理过程 缓解期 发作期 血浆 EEG GSH 

分 类 号：R285.5[医药卫生—中药学] R473.74[医药卫生—中医学]