复方氨基酸对低体重儿血清和脑脊液中Glu、Asp水平的影响  

The Affact of Composite Amino Acids on Glutamate and Aspartate in Cerebrospinal Fluid and Serum in Low Birth Weight Infants

作　　者：俞生林[1] 张瑞宣[1] 肖志辉[1] 冯星[1] 丁晓春[1] 朱雪萍[1] 詹晓斌[1] 蒋滢[2] 黄美英[2] 

机构地区：[1]苏州医学院附属儿童医院新生儿病房，苏州，215003 [2]苏州医学院生物化学教研室

出　　处：《苏州医学院学报》2000年第10期904-905,共2页Acta Academiae Medicinae Suzhou

摘　　要：目的　研究复方氨基酸对低出生体重儿中枢神经系统的可能影响。方法　采用丹酰氯 -聚酰胺薄层层析法测定 2 0例全能营养液 (TNA)治疗低体重儿和 2 0例非TNA治疗 (对照组 )低体重儿血清和脑脊液中谷氨酸(Glu)、天冬氨酸 (Asp)水平。 结果　治疗后TNA组血清中Glu、Asp皆显著提高 (P <0 .0 1) ,而脑脊液中Glu、Asp无显著差异 (P >0 .0 5 ) ;对照组中两者均无明显差异 (P >0 .0 5 ) ;TNA组脑脊液中Glu、Asp之间呈正相关 (r =0 .79,P <0 .0 0 1) ;血清中Glu、Asp分别与脑脊液中Glu、Asp均无相关性 (分别是r =0 .32 8,P >0 .0 5 ;r =0 .334,P>0 .0 5 )。结论　静脉使用复方氨基酸于低体重儿对其脑脊液中Glu。To explore possible affact of composite amino acids on central nerve system of low birth weight (LBW) infants.Concentrations of glutamate (Glu) and aspartate (Asp) in cerebrospinal fluid (CSF) and serum in LBW infants ( n =20) treated with Total Nutrient Admixture (TNA),control group ( n =20) in which only glucose was given and electrolytes were determined by dimethylamino-naphthalene-S-sulfonyl chloride with thin layer chromatography (TLC) and fluoromtry.The results showed that:(1) in TNA group the Glu and Asp in serum increased significantly after treatment,but Glu and Asp in CSF before treatment showed no significant difference as compared with that after treatment.(2) in control group Glu and Asp in serum and CSF before treatment showed no significant difference as compared with that after treatment.(3) in TNA group Glu was positively correlated with Asp in CSF,but these was no correlation between Glu and Asp in CSF in serum,respectively.Those results suggeste that composite amino acids have no affact on the levels of Glu and Asp in CSF in LBW infants.

关 键 词：复方氨基酸 低体重儿 GLU 脑脊液 P水平 血清 中枢神经系统 低出生体重儿 P〉0.05 全能营养液 薄层层析法 Asp TNA 天冬氨酸 对照组 谷氨酸 聚酰胺 治疗后 正相关 相关性 

分 类 号：R977.4[医药卫生—药品] R722[医药卫生—药学]