维生素C、别嘌呤醇对大鼠冷束缚应激性损伤的影响  

Effects of Vitamin C and Allopurinol on the injuries induced by cold-restraint-stress in rats

作　　者：黄林邦[1] 申力[1] 韩光[1] 王市农[2] 张文峰[3] 

机构地区：[1]赣南医学院病理生理学教研室 [2]赣南医学院病理学教研室 [3]赣南医学院生化学教研室

出　　处：《赣南医学院学报》1993年第4期197-200,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：江西省科委二级计划课题

摘　　要：本实验观察了维生素C(A组)、别嘌呤醇(B组)和两药合用(C组)、对SD大鼠冷束缚应激性损伤的影响。并与生理盐水组(D组) 和次黄嘌呤-黄嘌呤氧化酶组(E组)进行比较。结果显示,在动物出现的应激性损伤和体内脂质过氧化反应方面,B、C组较轻,具有一定的保护作用(P<0.05),A组与D、E组之间无显著性差异(P>0.05);提示维生素C对冷束缚应激动物无益。The effects of Vitamin C ( group A) , Allopurinol ( group B) and combination of these two medicines ( group C) on the injuries induced by cold-restraint-stress in SD rats have been observed in the experiment. The observational re-sults of the three groups above have been compared with those of saline group ( group D) and Hypoxanthine- xanthine oxidase group ( group E) It is showed that the stress-induced injuries and lipid peroxidation in vivo are milder in group B and C (P<0.05) and not significant in group A (P>0.05), as com-parec with those of group D and E.The results suggest that Vitamin C will be of no help for the animals which have undergone cold-restraint-stress.

关 键 词：应激性损伤 维生素C 别嘌呤醇 脂质过氧化反应 黄嘌呤氧化酶 生理盐水组 显著性差异 冷束缚应激 实验观察 SD大鼠 次黄嘌呤 保护作用 C组 动物 

分 类 号：R285.5[医药卫生—中药学] R977.23[医药卫生—中医学]