刺激小脑顶核对C类纤维传入诱发大脑皮层电反应的影响及其机制  

Effect and mechanism of fastigial nucleus stimulation on electric response of somatosensory cortex induced by C-fiber input

作　　者：王家萍[1] 陈助华[2] 吴杰[2] 陈培熹[2] 

机构地区：[1]赣南医学院生理教研室 [2]中山医科大学

出　　处：《赣南医学院学报》1993年第4期204-208,共5页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：采用极化电流阻断技术、选择性引起猫隐神经C类纤维传入,在大脑皮层体感Ⅰ区记录平均诱发电位(C-CEP),作为慢痛反应的指标,观察电刺激小脑顶核(FN)对C-CEP的影响。结果表明:电刺激小脑顶核可以明显抑制C-CEP;静脉注射赛庚啶或纳洛酮均可以明显减弱FN对C-CEP的抑制作用,提示FN可以抑制大脑皮层慢痛反应;5-羟色胺和内源性吗啡样物质可能参与FN抑制C-CEP的作用。The effect of FN stimulation on the cortical potential evoked by C-fiber input in SI was explored.The results show that the inhibitory effect on C-CEP of FN stimulation with higher frequency is obvious and FN may participate in the modulation of C-CEP, and the intrarenous injection of cyproheptadine ornaloxone can diminish the inhibition of FN stimulation on C-CEP, indicating that OLS and 5-HT might participate in the inhibition of FN on C-CEP and might be the main neurotransmitter.

关 键 词：皮层电反应 电刺激小脑顶核 核对 神经C类纤维 大脑皮层 吗啡样物质 5-羟色胺 CEP 阻断技术 诱发电位 体感Ⅰ区 抑制作用 静脉注射 痛反应 FN 纳洛酮 赛庚啶 内源性 

分 类 号：R339.16[医药卫生—人体生理学] R743.33[医药卫生—基础医学]