小剂量盐酸二氢埃托啡,654-2治疗海洛因依赖40例疗效分析  

CLINICAL EFFICACY OF SMALL DOSAGE OF DIHYDROETORPHINE HYDROCHLORIDE COMBINED WITH ANISODAMINE IN THE TREATMENT OF 40 CASES OF HEROIN ADDICTS

作　　者：苏木金[1] 林云[1] 沈天光[1] 张蕾[1] 黄华[1] 

机构地区：[1]解放军广州疗养院,广州510515

出　　处：《中国药物依赖性通报》1993年第1期48-51,共4页

摘　　要：本文以小剂量盐酸二氢埃托啡(DHE)与山莨菪碱(654-2)伍用静滴,10 d一疗程,治疗海洛因依赖40例,其中戒断12例,显效22例,减轻6例,戒毒率85%。与单一使用常量DHE对照治疗组20例的戒毒率(80%)进行比较,二者无显著性差异(P>0.05)。认为本疗法减药时控制症状比较平稳,副作用少,654-2本身无成瘾性,是一种较好的海洛因依赖患者戒毒疗法。Small dosage of dihydroetorphine hydrochloride (DHE)combined with anisodamine was used in the treatment of 40 cases of heroin addicts. Drugs were given by intravenous infusion in seven days course. Results showed that 12 cases were detoxified, 22 cases were highly effective, 6 cases were alleviat- ed, the detoxification rate was 85%. There was no significant difference (P> 0.05) when compared with the detoxification rate (80%) of the control group using ordinary dosage of DHE. It was shown that during the period of medication, the control of abstinence syndromes was quite stable in process of gradual reduction of dosage and side effects were few. Anisodamine has no dependence- producing property. It is concluded that the present method is effective in the treatment of heroin dependence.

关 键 词：盐酸二氢埃托啡 海洛因依赖 654-2治疗 小剂量 疗效分析 显著性差异 山莨菪碱 症状比较 戒毒疗法 治疗组 DHE 成瘾性 副作用 

分 类 号：R971.1[医药卫生—药品] R595.5[医药卫生—药学]