烫吸方式的阿片滥用者细胞免疫功能的研究  

A STUDY ON CELLULAR IMMUNOLOGIC STATUS OF INHALANT HEROIN ADDICTS

作　　者：刘志民[1] 唐军民[2] 孙桂宽[1] 唐岩[2] 刘湛[1] 李欣光[1] 王凯[1] 蔡志基[1] 王小平 王哲[4] 

机构地区：[1]北京医科大学中国药物依赖性研究所,北京100083 [2]北京医科大学基础医学院,北京100083 [3]西安市碑林区戒毒所,西安710048 [4]中国预防医学科学院病毒学研究所艾滋病研究与检测中心,北京100052

出　　处：《中国药物依赖性通报》1993年第4期239-241,246,共4页

摘　　要：本文对20例烫吸方式的阿片滥用者进行了Et花环、PHA T淋巴细胞转化率和淋巴细胞α-醋酸萘酯酶(ANAE)等实验,测定滥用者细胞免疫功能。结果表明,阿片滥用组外周血中Et值虽属正常范围的下限,但低于正常平均水平,并显著低于该地区对照组平均水平(P<0.05);PHA T淋巴细胞转化率虽也属正常范围,但也显著低于该地区对照组水平(P<0.05)。提示烫吸方式的阿片滥用对细胞免疫功能具有一定的抑制性作用,但不排除滥用者中多种药物滥用和营养不良等因素对免疫功能的可能影响。Cellular immunologic status of 20 inhalant heroin addicts (IHDAs) was studied. The results showed that compared with the control there was impairment in mi- togen response of cultured T-lymphocytes in peripheral blood (P<0.05); ability of lym- phocyte to rosette sheep red blood cells (SRBC) was low (P<0.05), 12 of the addicts had infective complication, indicating that abnormalities appeared in cellular immune system in chronic IHDAs. However, the factors of polydrug use such as tobacco, alcohol and even DHE, the presence of concurrent infection, and nutritional status of the addicts cannot be excluded.

关 键 词：细胞免疫功能 烫吸方式 滥用者 T淋巴细胞转化率 α-醋酸萘酯酶 正常范围 阿片滥用 平均水平 营养不良 药物滥用 PHA 对照组 外周血 抑制性 等因素 

分 类 号：R285.5[医药卫生—中药学] R742[医药卫生—中医学]