电针频率是决定家兔电针镇痛效果是否能被钠洛酮阻断的重要因素  

FREQUENCY OF ELECTROACUPUNCTURE AS A CARDINAL FACTOR DETERMINING THE POTENCY OF ANALGESIA AND ITS VULNERABILITY TO NALOXONE BLOCKADE IN RABBITS

作　　者：王晓民[1] 周仲福[1] 韩济生[1] 

机构地区：[1]北京医科大学生理教研室

出　　处：《针刺研究》1989年第1期141-142,共2页Acupuncture Research

摘　　要：本工作以2．0～2．6公斤的雄性家兔为实验对象，以甩头或甩尾反应的潜伏期ERL作为观测指标，观察了电针“足三里”和“昆仑”镇痛的适宜频率和纳洛酮对不同频率电针镇病的阻断作用。结果表明，不论头部或尾部测痛都是2～15Hz的镇痛作用最强，其次为15Hz≥2Hz>30Hz>60Hz≥100Hz。将各频率组的头部电针有效率与尾部电针有效率分别进行x^2检验，发现两者之间的差异无统计学意义。Male rabbits of 2 0-2.6kg were used. nociception was assessed by measuringthe latency of the escape response (ERL) elicited by strong radiant heat focused on the skin of the nostrils or on the tail. Electroacupunctre (EA) stimulationwas applied via acupuncture needles inserted into the acupoint Zusanli andQuenlun, located near the knee joint and ankle joint respectively, A 50% increasein ERL at the end of 10 min EA stimulation was considered as positive responsein EA analgesia. The effectivenese of EA analgesia was determined usingEA of different frequencies, ranging from 2, 2—15, 15, 30, up to 60 and 100Hz with the intensify of EA being fixed at 2 volts (2.24±0.11mA). Thepercentage of responders was highest in 2-15 Hz EA (70%), followed by 15Hz≥2 Hz>30Hz, whereas 60 and 100 Hz EA were practically ineffective(responders only 12--13%). The rate of responders as determined by nociceptivetest applie on the head showed no significant difference with those applied onthe tall, indicating that the analgesic effect is generalized rather than segmental.The vulnerability of EA analgesia to naloxone blockade depends on the frequencyof EA being used. The analgesic effect of 2 Hz & 2-15 Hz EA could be blockedby a small dosc (1mg/kg) of naloxone, that of 15 Hz EA by a higher dose(5mg/kg), whereas the effect of 30 Hz HA could not be blocked even by 10mg/kg of naloxone. The results suggest that low frequency (2 Hz, 2-15 Hz) EAanalgesia is mediated predominantly, and 15 Hz EA analgesia partly, by opioidmechanisms, whereas higher frequency (30 Hz or more) EA analgesia seems tobe mediated by non-opioid mechanisms.

关 键 词：镇痛效果 电针频率 钠洛酮 “足三里” 100Hz X^2检验 实验对象 雄性家兔 观测指标 甩尾反应 阻断作用 不同频率 镇痛作用 头部电针 有效率 潜伏期 纳洛酮 统计学 尾部 

分 类 号：R169.42[医药卫生—公共卫生与预防医学] R245.97