^(18)F标记乏氧组织显像剂的研究进展  

The Development ^(18)F Labeled Hypoxic Imaging Agents

作　　者：汪建军[1] 张剑英[1] 朱霖[1] 

机构地区：[1]放射性药物教育部重点实验室,北京师范大学化学系,北京100875

出　　处：《同位素》2004年第4期241-246,共6页Journal of Isotopes

摘　　要：乏氧组织显像剂是当前放射性药物研究的热点之一。随着PET显像技术的迅速发展,18F标记的放射 性药物在临床上的应用越来越广泛。18FMISO(18F-氟米索硝唑)是现今核医学领域研究最多的18F标记的乏 氧组织显像剂,它自身存在一些缺点,而新的乏氧组织显像剂仍在进一步的研究中。The development of 18F labeled hypoxic agents for PET imaging is mainly introduced. With the rapid development of PET imaging technique, the application of radiopharmaceuticals labeled with 18F in nuclear medicine becomes more and more widely and the hypoxic agents become the hot spots in recent radiopharmaceutical research. 18FMISO is the mostly studied of I8F labeled hypoxic agents in clinic. But because of 18FMISO having some defect, some new hypoxic agents are still need to be researched.

关 键 词：^18F 乏氧组织显像剂 肿瘤 标记 

分 类 号：R817.9[医药卫生—影像医学与核医学] R817.4[医药卫生—放射医学]