积雪草总苷对实验性抑郁症大鼠血清皮质酮和单胺类神经递质的影响  

Effects of Total Triterpenes of Centella asiatica on the Corticosterone Levels in Serum and Contents of Monoamine in Depression Rat Brain

作　　者：陈瑶[1] 韩婷[2] 芮耀诚[2] 殷明[1] 秦路平[2] 郑汉臣[2] 

机构地区：[1]上海交通大学药学院,上海200030 [2]第二军医大学药学院,上海200433

出　　处：《中药材》2005年第6期492-496,共5页Journal of Chinese Medicinal Materials

基　　金：军队"十五"指令性课题(01L058);国家自然科学基金(30100242)

摘　　要：目的探讨积雪草总苷抗抑郁症可能的作用机制。方法采用荧光法检测积雪草总苷对实验性抑郁症大鼠血清皮质酮的影响;HPLCECD法检测积雪总苷对大鼠皮质、海马和下丘脑单胺类神经递质含量的影响。结果积雪草总苷降低抑郁症大鼠的血清皮质酮水平,增加脑内5HT,NE和DA及其代谢产物的含量。结论积雪草总苷的抗抑郁活性与改善下丘脑垂体肾上腺轴功能和增加胺神经递质的水平有关。Objective: To investigate the possible effect of antidepressant effect of total triterpentes of Centella asiatica. Methods: The corticosterone levels in serum were measured by fluorescence spectroscopy. The contents of monoamine neurotransmitters and their metabolites in rats cortex, hippocamopus and thalamus were evaluated by using HPLC with electrochemical detector. Results: Significant reduction of the corticosterone level in serum and increase of the contents of 5-HT, NE, DA and their metabolites 5-HIAA, MHPG in rat brain were observed. Conclusion: The antidepressant effect of total triterpenes of Centella asiatica may be involved in ameliorating the function of HPA axis and increasing the contents of monoamine neurotransmitters.

关 键 词：积雪草总苷 大鼠血清 单胺类神经递质 皮质酮 实验性 垂体-肾上腺轴功能 神经递质含量 抗抑郁活性 作用机制 抗抑郁症 HPLC 5-HT 代谢产物 下丘脑 荧光法 CD法 检测 水平 

分 类 号：R284.2[医药卫生—中药学] R575.2[医药卫生—中医学]