砂仁挥发油中乙酸龙脑酯的镇痛作用及其机制研究  

Research on the Analgesic Effect and Mechanism of Bornyl Acetate in Volatile Oil from Amomum Villosum

作　　者：吴晓松[1] 肖飞[2] 张志东[1] 李晓光[2] 徐珍霞[2] 

机构地区：[1]暨南大学附属第一医院,广州510630 [2]暨南大学药学院,广州510632

出　　处：《中药材》2005年第6期505-507,共3页Journal of Chinese Medicinal Materials

基　　金：广东省中医药局科研资助项目(102042)

摘　　要：目的研究砂仁挥发油主要成分乙酸龙脑酯的镇痛作用及机制。方法采用大鼠尾尖压痛实验观察乙酸龙脑酯的镇痛作用;福尔马林实验观察其Ⅰ相和Ⅱ相疼痛反应;纳洛酮拮抗实验观察对乙酸龙脑酯镇痛作用的影响。结果乙酸龙脑酯可提高尾尖压痛大鼠的痛阈值;对福尔马林致痛模型动物Ⅰ相和Ⅱ相疼痛反应均有抑制作用;纳洛酮未能显著减弱乙酸龙脑酯的镇痛作用。结论乙酸龙脑酯具有较显著的镇痛作用;其镇痛作用部位即在外周神经末梢,亦可能在中枢神经;镇痛作用机制可能不同于阿片类药物。Objective:To study the analgesic effect and mechanism of bornyl acetate,the main ingredient of Amomum Villosum Volatile oil. Methods:The analgesic effects were tested by pressing tail method.The Ⅰ, and Ⅱ phase pain were observed with the pain model caused by formalin test.Influence of naloxone antagonism test on analgesic effect of bornyl acetate.Results:Bornyl acetate produced obvious analgesic effects on pain models induced by pressing tail.Bornyl acetate had inhibitory effect on Ⅰ and Ⅱ phase pain in formalin inducing pain model animals. Analgesic effect induced by Bornyl acetate wasn’t significantly reduced by naloxone.Conclusion:Bornyl acetate shows analgesic effects.The analgesic site may locate in both central and peripheral nervous system.Its analgesic action way not be related to the opioid receptor.

关 键 词：乙酸龙脑酯 镇痛作用 砂仁挥发油 机制研究 实验观察 福尔马林致痛 外周神经末梢 疼痛反应 阿片类药物 主要成分 抑制作用 模型动物 作用部位 中枢神经 作用机制 纳洛酮 痛阈值 压痛 

分 类 号：R285.5[医药卫生—中药学] R284.2[医药卫生—中医学]