宫颈癌及癌前病变患者人乳头瘤病毒感染率的临床分析  

Clinical Analysis of the Infection Rate of Human Papillomavirus in Women with Cervical Carcinoma and Precancerous Lesion

作　　者：张燕玲[1] 乔志强[1] 李隆玉[1] 万磊[1] 

机构地区：[1]江西省妇幼保健院肿瘤科,330006

出　　处：《实用癌症杂志》2005年第2期161-163,共3页The Practical Journal of Cancer

摘　　要：目的探讨宫颈癌及癌前病变与人乳头瘤病毒感染率的关系。方法2003年3月～2004年8月随机顺序选取江西省妇幼保健院肿瘤科不同程度宫颈病变的住院患者832例,采用第二代杂交捕获试验(HybridCaptureⅡ,HCⅡ)对所有患者宫颈脱落细胞行HPVDNA定量检测,分别对不同程度宫颈病变与HPVDNA检测阳性率进行分析,所有患者HPVDNA检测均在首次入院时,未接受任何检查及治疗、无任何干预措施的情况下进行。全部受检者最终诊断均经病理检查确诊为宫颈癌或宫颈上皮内瘤变(CIN)。临床诊断根据1994年FIGO(国际妇产科联盟)分期标准。结果832例宫颈病变患者中,CIN352例,其中CINI59例,CINⅡ107例,CINⅢ186例;宫颈浸润癌(SCC)480例。CINⅠ、CINⅡ、CINⅢ的HPVDNA感染率分别为67.79%、79.44%、89.25%;宫颈癌480例,Ⅰ期122例,Ⅱ期185例,Ⅲ期173例,HPVDNA感染率分别为90.98%、91.35%、93.64%。结论宫颈脱落细胞HPV感染率随宫颈病变程度的加重而升高。不同程度CIN患者的HPV感染率有显著差异(P<0.05),宫颈浸润癌患者HPV感染率明显高于癌前病变患者(P<0.05),而不同期别浸润癌患者之间HPV感染率无显著性差异(P>0.05)。Objective To determine the relationship between the infection rate of human papillomavirus with cervical carcinoma and precancerous lesion.Methods From March 2003 to August 2004,a total of 832 inpatient with cervical lesions in various degrees in our hospital were selected randomly in sequence.All specimens were detected for HPV using hybrid capture Ⅱ(HC-Ⅱ).We analysed the HPV infection rate in patients with different pathological types and different stages of cervical carcinoma and precancerous lesion.All detections were performed before any other examination and treatment.All the diagnosis was documented by pathological examination.Clinical stages were made according to the standard of FIGO in 1994.Results 352 women were diagnosed as cervical intraepithelial neoplasia(CIN).The infection rates were 67.79%、79.44%、89.25% in CINⅠ、CINⅡ、CINⅢ respectively.480 women were diagnosed as squamous cervical carcinoma.The infection rates were 90.98%、91.35%、93.64% in stageⅠ、stageⅡ and stageⅢ of cervical carcinoma.Conclusion The infection rates increase with the raise of cervical lesion stage.The infection rate in women with cervical squamous cell carcinoma is significantly higher than that in women with CIN(P<0.05).But the difference of HPV infection in women with different stage of cervical cancer is not significant(P>0.05).

关 键 词：病毒感染率 癌前病变 人乳头瘤 宫颈癌 临床分析 江西省妇幼保健院 宫颈脱落细胞 2003年3月 DNA定量检测 宫颈上皮内瘤变 国际妇产科联盟 HPV-DNA DNA检测 宫颈病变 不同程度 CINⅡ 2004年 1994年 宫颈浸润癌 显著性差异 

分 类 号：R512.91[医药卫生—内科学] R735.2[医药卫生—临床医学]