腕踝针对肝癌疼痛的镇痛疗效及对神经肽类物质的影响  

Analgesic Efficacy and Mechanism of Wrist-ankle Acupuncture on Pain Caused by Liver Cancer

作　　者：胡侠[1] 顾伟[1] 周庆辉[1] 凌昌全[1] 

机构地区：[1]第二军医大学附属长海医院中医科,上海200433

出　　处：《中西医结合肝病杂志》2005年第3期131-133,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:观察腕踝针对中重度肝癌疼痛的镇痛效果及对体内神经肽类物质的影响。方法:将94例肝癌疼痛患者根据疼痛程度分为5组,中度疼痛2组,重度疼痛3组,观察各组的缓解率、不良反应及对体内血浆β内啡肽与P物质(SP)的影响。结果:腕踝针对中度疼痛缓解率为85%,对重度疼痛缓解率为63%,针药结合缓解率为83.33%。针刺组患者治疗前后β内啡肽指标分别为(29.4±22.57)、(67.47±40.34)pg/ml,治疗前后体内的SP指标分别为(42.26±13.00)、(30.92±8.34)pg/ml。结论:腕踝针治疗中重度肝癌疼痛疗效肯定,对重度疼痛结合药物能降低不良反应发生率,同时引起体内血浆β内啡肽的释放与SP的抑制。Objective:To assess the analgesic efficacy and mechanism of the wrist-ankle acupuncture in the treatment of the moderate and severe pain of liver cancer.Methods:94 patients were divided into 5 groups randomly. 40patients with moderate pain were divided into 2 groups(wrist-ankle acupuncture,codeine treatment).54 patients with severe cancer pain were divided into 3 groups(wrist-ankle acupuncture, acupuncture combined with MS Contin, MS Contin).Pain relief rate, side effects and the contents of the patients'plasma β-endorphin and substance P were observed. Results: The pain relief rate of the wrist-ankle acupuncture in moderate pain group were 85%,and 63% in severe pain group. Acupuncture combined with MS Contin reached to 83.33%. The contents of the patients' plasma β-endorphin and substance P before and after treatment were (29.4±22.57)、(67.47±40.34)pg/ml and (42.26±13.00)、(30.92±8.34)pg/ml respectively.Conclusion:The present studies confirm the analgesic efficacy of the wrist-ankle acupuncture therapy to the cancer pain caused by heptocarcinoma, especially to the moderate pain.

关 键 词：神经肽类物质 肝癌疼痛 镇痛疗效 血浆Β-内啡肽 不良反应发生率 疼痛缓解率 重度疼痛 治疗前后 腕踝针治疗 镇痛效果 疼痛程度 疼痛患者 中度疼痛 针药结合 结合药物 中重度 体内 P物质 指标 SP 

分 类 号：R246[医药卫生—针灸推拿学]