湖北地区特殊人群庚型肝炎病毒感染状况及其影响因素  

The Prevalence and Associated Risk Factors of HGV in Drug Users and Prostitutes

作　　者：张振纲 [1] 田德英 [1] 夏宁邵 [2] 黄加权 [2] 黄元成 [1] 杨道锋 [1] 陈红云 [1] 雷洪波 [1] 宋佩辉 [1] 

机构地区：[1]华中科技大学同济医学院附属同济医院感染科,湖北,武汉,430030 [2]厦门大学国家基因工程重点实验室

出　　处：《中西医结合肝病杂志》2005年第3期159-161,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：受863课题资助(102-07-02-07)

摘　　要：目的:调查湖北地区性滥者和药瘾者HGV感染状况及其影响因素。方法:检查药瘾者和性滥者的血清HGV感染指标,用ELISA法检测抗HGV。结果:2206例标本中普通健康体检者1257例;949例为特殊人群(药隐者716例,性滥者309例,其中76例既是药瘾者又是性滥者),其HGV感染率分别为12.85%(75/716)、11.97%(20/309)、22.37%(17/76),均显著高于普通人群(1.51%,19/1257)。药瘾和性滥2年以上者抗HGV阳性率(19.41%,17.05%)显著高于药瘾和性滥2年以下者(8.01%,5.26%;χ2分别为19.29和8.89,P<0.01);静脉药瘾者抗HGV阳性率(16.96%)与口服药瘾者(5.73%)比较差异有显著性意义(χ2=108.31,P<0.05);性别和HBV感染对药瘾和性滥者抗HGV阳性率的高低没有影响(χ2分别为1.36和1.59,P>0.05);抗HCV(+)者和抗HCV(-)者的抗HGV阳性率差异有显著性意义(χ2分别为19.26和4.25,P<0.05)。所有HGV感染者的肝功能正常。结论:药瘾者和性滥者均具有较高的HGV感染率。其HGV感染率与吸毒时间或性滥时间呈正相关。Objective:To survey the prevalence and the associated risk factors of HGV in the drug users and prostitutes. Methods: Anti-HGV was detected by ELISA. Results: The positive rate of HGV markers in drug users and prostitutes was 12.85% (92/716) and 11.97%(37/309). The positive rate of Anti-HGV in i.v. drug users(16.96%) was higher than that in oral users(5.75%,χ~2=108.31, P<0.05).There weren′t difference of positive rates of anti-HGV between female (14.49%,12.36%)and male(11.32%,10%,χ~2=1.36 respectively,P>0.05);between users with positive HBsAg (14.22%) and users with negative HBsAg (11.04%,χ~2=1.31,P>0.05);between prostitutes with positive HBsAg (15.38%) and prostitetes with negative HBsAg (9.90%,χ~2=1.59,P>0.05).However, difference were found between users addicted for more than 2 years(19.41%)and users for less than 2 years (8.01%,χ~2=19.29,P<0.01); between female users with prostitution (22.37%) and femae without prostitution (12.27%,χ~2=4.10,P<0.05); between users with positive anti-HCV (16.99%)and users with negative anti-HCV (5.18%,χ~2=19.26,P<0.05);between prostitutes with positive anti-HCV (16.99%)and prostitutes with negative anti-HCV (8.24%,χ~2=4.25,P<0.05).No abnormality of liver function was found in all of the cases with positive HGV markers. Conclusion:Drug addiction and prostitution increases the risk of HGV infection.

关 键 词：庚型肝炎病毒感染状况 特殊人群 湖北地区 抗-HGV ELISA法检测 健康体检者 静脉药瘾者 HBV感染 肝功能正常 感染率 阳性率 感染指标 普通人群 吸毒时间 显著性 地区性 感染者 正相关 

分 类 号：R512.6[医药卫生—内科学]