衡阳地区淋病奈瑟菌流行株对大环内酯类药物敏感性的研究  

Study on the Susceptibility of Neisseria gonorrhoeae Epidemic Strains to Macrolides in Hengyang

作　　者：杨胜辉[1] 余敏君[1] 吴移谋[1] 胡四海[1] 谭立志[1] 冯敏 黄澍杰 

机构地区：[1]南华大学医学微生物学与免疫学教研室,湖南衡阳421001 [2]衡阳市中心医院 [3]广东省江门市皮肤病防治所

出　　处：《南华大学学报（医学版）》2005年第3期322-325,共4页Journal of Nanhua University(Medical Edition)

基　　金：湖南省科技厅基金(课题编号01SSY2008-6);教育厅基金(4-01-JY-01C198;02C398)资助.

摘　　要：目的了解淋病奈瑟菌流行株对大环内酯类药物的敏感性,为淋病的防治提供实验依据。方法采用琼脂稀释法对分离出的101株淋球菌流行株进行了药物敏感性测定。结果在测定的4种大环内酯类药物中,淋球菌对阿奇霉素敏感性最高,达100%;其次为罗红霉素,为96.04%。交沙霉素耐药率最高,达36.63%;红霉素耐药率其次,为20.79%;罗红霉素耐药率仅为3.96%。结论阿奇霉素可作为衡阳地区淋病治疗的首选药物,罗红霉素可作为淋病治疗的替代性药物。淋球菌对大环内酯类药物有一定的不完全交叉耐药性。Objective To evaluate the antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains to macrolides in Hengyang and provide a referrence for the prevention and treatment of gonorrhea. Methods 101 gonococcal isolates obtained from 2003 to 2004 in Hengyang city , Hunan province , were tested for their susceptibilities to macrolides using agar dilution method. Results Of all these 4 macrolides, the higher susceptibilities to gonococci were azithromycin and roxithromycin, in turn , the percentages of susceptibility were 100%, 96.04% , respectively .On the other hand , the higher resistances to gonococci were josamycin, erythromycin and roxithromycin, the percentages of resistance were 36.63%, 20.79% 3.96%, respectively. Conclusion Azithromycin can be used as first-line agents to cure gonorrhea and roxithromycin used for alternative agents. Neisseria gonorrhoeae has some certain cross-resistance to macrolides.

关 键 词：淋病奈瑟菌 琼脂稀释法 抗生素敏感性 最低抑菌浓度(MIC) 

分 类 号：R759.2[医药卫生—皮肤病学与性病学]