自发性高血压大鼠颈动脉血管平滑肌中抑癌基因P53和原癌基因c-jun、c-fos、c-mycmRNA表达的研究  

The Effect of ACEI on Expression of Tumor Suppressor Gene and Oncogenes in Carotid Smooth Muscle From the Spontaneous Hypertension Rats

作　　者：刘洪 向前 祝平菊 孙明[2] 尹卫东[3] 刘英山 

机构地区：[1]深圳市南山医院,广东深圳518051 [2]中南大学附属湘雅医院,湖南长沙410078 [3]南华大学医学院,湖南衡阳421001

出　　处：《南华大学学报（医学版）》2005年第3期347-349,共3页Journal of Nanhua University(Medical Edition)

基　　金：深圳市科技局课题(批准号980013).

摘　　要：目的探讨自发性高血压大鼠颈动脉中抑癌基因P53和原癌基因c-jun、c-fos、c-mycmRNA的表达。方法用逆转录聚合酶链式反应检测两种基因的表达水平。正常雄性大鼠作为对照组。结果SHR颈动脉中,抑癌基因P53和原癌基因c-jun、c-fos、c-myc均有高表达,较WKY差异有显著性(P<0.05)。结论自发性高血压大鼠颈动脉组织中抑癌基因P53和原癌基因c-jun、c-fos、c-myc均有高表达,癌基因的活化可能与自发性高血压大鼠颈动脉血管重构有关。Objective To study the mRNA expression of tumor suppressor gene P53 and oncogene c-jun,c-fos,c-myc in carotid smooth muscle from the spontaneous hypertension rat (SHR). Methods The mRNA expression of these genes were examined by RT-PCR. WKY was experimented as control group. Results The mRNA of these genes expressed obviously in SHR, and had evident difference compared with WKY'(P<0.05). Conclusion In SHR carotid smooth muscle ,the expression of tumor suppressor gene P53 and oncogene c-jun,c-fos and c-myc expressed obviously. The expression probably related to carotid reconstruction.

关 键 词：自发性高血压大鼠 抑癌基因 原癌基因 血管重构 

分 类 号：R544.1[医药卫生—心血管疾病]