梗阻性黄疸患者红细胞膜脂变化的研究  

Clinical study on the changes in RBC membrane lipids in patients with obstructive jaundice

作　　者：朱建平[1] 林昀[2] 沈子威[3] 徐智[1] 

机构地区：[1]北京医科大学第三临床医学院外科,100083 [2]中国科学院动物研究所 [3]清华大学生物膜与膜生物工程国家重点实验室

出　　处：《中华实验外科杂志》1998年第2期121-122,共2页Chinese Journal of Experimental Surgery

摘　　要：目的探讨梗阻性黄疽病人胆红素的毒性机理。方法采用质谱法测定梗阻性黄疽病人减黄术前后的红细胞膜脂变化。结果减黄术后两周,病人红细胞膜脂的长链脂肪酸、不饱和脂肪酸增多,双键含量增加,膜脂成分趋向正常。结论减黄术能改善梗阻性黄疽病人的红细胞膜结构与功能。Objective To investigate the toxicology of bilirubin in the patients with obstructive jaundice. Method The changes in RBC membrane lipids in the patients with obstructive jaundice before and after biliary drainage operation were studied by gas chromatography-mass spectrometry (GC-MS). Result The levels of unsaturated and long chain fatty acids in RBC membrane were increased, and the contents of RBC membrane lipids turned to normal 2 weeks after biliary drainage. Conclusion The biliary drainage operation might improve the structure and function of cell membrane in the patients with obstructive jaundice.

关 键 词：红细胞膜脂 梗阻性黄疸病人 患者 不饱和脂肪酸 梗阻性黄疽 长链脂肪酸 细胞膜结构 毒性机理 胆红素 术前后 质谱法 减黄术 

分 类 号：R541.4[医药卫生—心血管疾病] R575[医药卫生—内科学]