补肾活血方对膝骨性关节炎模型家兔一氧化氮水平的影响  

Effects of Chinese Herbs of Strengthening Kidney and Activating Blood on the Level of the Nitric Oxide in Rabbits with Knee Osteoarthritis

作　　者：牛维[1] 邵敏[1] 黎高明[2] 

机构地区：[1]广州中医药大学附属骨伤科医院,广东广州510240 [2]广州中医药大学

出　　处：《安徽中医学院学报》2005年第3期26-28,共3页Journal of Anhui Traditional Chinese Medical College

基　　金：广东省自然科学基金资助项目(020791);国家中医药管理局科学技术研究专项基金资助项目(0203JP33)

摘　　要：目的:探讨补肾活血方对骨性关节炎模型家兔血清、关节软骨及滑膜中一氧化氮(NO)含量的影响。方法:54只10月龄新西兰大白兔,随机分为正常组、模型组、中药组各18只。采用Hulth模型复制法建立骨性关节炎模型,模型复制后4周正常组和模型组给予9.0g/L氯化钠注射液,中药组给予补肾中药灌服。分别于模型复制后4,8,12周测定各组血清、关节软骨及滑膜NO含量。结果:模型组血清、关节软骨及滑膜NO水平均高于正常组,以滑膜最为显著,而灌服中药后各项指标有明显下降,与模型组相比差异有显著性(P<0.01)。结论:补肾活血中药能够降低骨性关节炎血清、关节软骨和滑膜中NO水平,抑制骨性关节炎的发生和发展。Objective:To explore the effects of Chinese herbs of strengthening kidney and activating blood on netric oxide (NO) of serum, articular cartilage and synovial membrane in rabbits′ knee joints. Method: Fifty four New Zealand rabbits with 10 months were divided randomly into the normal group, model group and Chinese herb group. The rabbits in normal group underwent sham operation and others established the OA model with Hulth′s method. Chinese herb group were given Chinese herbs.The NO concentration of the serum, articular cartilage and synovial membrane in all rabbits were examined at 4, 8 ,12 weeks after operation. Result: The NO concentration of the serum, articular cartilage and synovial membrane in model group was all significantly higher than those in normal group, with the synovial membrane more obvious than others′. Compared with other groups, the NO concentration of Chinese herb group were obviously decreased( P <0.05). Conclusion:The Chinese herbs of strengthening kidney and activating blood was effective in preventing and treating osteoarthritis by decreasing the level of NO of the serum, synovial membrane and articular cartilage.

关 键 词：骨性关节炎 膝关节炎 补肾活血 补肾活血方 一氧化氮 

分 类 号：R684.3[医药卫生—骨科学]