氢化考地松对脂肪栓塞综合征血液流变性影响的实验研究  

Experimental Study of the Influence of Hydrogenation on the Blood Flow in Fat Embolism Syndrome

作　　者：戚其学[1] 张晓鹏[2] 

机构地区：[1]中国医科大学附属第一医院血液流变室,辽宁沈阳110001 [2]中国医科大学公共卫生学院中心实验室,辽宁沈阳110001

出　　处：《中国血液流变学杂志》2005年第1期16-18,共3页Chinese Journal of Hemorheology

摘　　要：目的　探讨氢化考地松对脂肪栓塞综合征血液流变性的影响。方法　应用血液流变学检测技术,测定了治疗组、未治疗组和对照组的全血粘度(ηb)、血浆粘度(ηp)、红细胞压积(Ht)、校正全血粘度(ηb′)、红细胞聚集指数(EAI)、及血小板和纤维蛋白原等各项指标,并对三者进行比较。结果　(1)治疗组血小板、纤维蛋白原指标保持比较稳定的水平,而未治疗组则表现为血小板减少和纤维蛋白原增高。未治疗组血小板计数与对照组比较有显著差别(P <0 .0 1) ,未治疗组与治疗组比较有显著性差异(P <0 .0 1)。未治疗组纤维蛋白原指标与对照组比较有显著性差异(P <0 .0 5 ) ,未治疗组与治疗组比较有显著性差异(P <0 .0 1)。(2 )治疗组、未治疗组及对照组三组间ηb无显著差异(P >0 .0 5 )。经校正后,治疗组与对照组间ηb′仍无显著性差异(P >0 .0 5 ) ,而未治疗组与治疗组、对照组比较:未治疗组ηb′显著增高(P <0 .0 5或P <0 .0 1)。(3)治疗组与对照组比较,ηp、Ht、EAI均无显著差异(P >0 .0 5 )。未治疗组与对照组、治疗组比较,ηp、EAI显著增高,Ht显著下降(P <0 .0 5或P <0 .0 1)。结论　FES血液多呈高粘滞状态。Objective To explore the influence of hydrogenation on the blood flow in fat embolism syndrome.Methods We determined the whole blood viscosity(ηb),plasma viscosity (ηp),red blood corpuscles,red blood cell gather index(EAI),platelet and fibrinogen by using the blood rheology detection techniques in the group of treatment, untreatment and control.Results (1) In the treatment group:Blood platelet and fibrinogen kept in steady level.While in the untreatment group the blood platelet reduced and fibrinogen increased. There were significant difference between the untreatment group and control(P<0.05).(2) In the treatment group:There is no significant difference in ηb between the untreatment group and control(P>0.05).After corrected,there was also no significant difference between the untreatment group and control.The ηb′ in the untreatment group increased significantlythan the control group(P<0.05 or P<0.01).(3) There were no significant differences in ηp,Ht,EAI between treatment group and control group (P>0.05).The ηp and Ht in the untreatment group were significantly higher and the Ht were significantly lower than those in the control and treatment group (P<0.05 or P<0.01).Conclusion FES blood is in high adhensive state,the reason is the inceased content of fibrin and the destrction gathering of blood platelet.

关 键 词：脂肪栓塞综合征 血液流变学 

分 类 号：R446.11[医药卫生—诊断学]