游泳锻炼对川芎嗪改善耳蜗微循环的影响  

Effect of the Swimming Training and Tertram Ethylplyrazine on the Microcirculation in Cochlea of Guinea Pigs After Chronic Hypoxia

作　　者：史艳莉[1] 黄元汛[1] 魏劲波[2] 

机构地区：[1]湖北大学体育学院,武汉430062 [2]武汉科技大学中南分校

出　　处：《听力学及言语疾病杂志》2005年第3期181-183,i001,共4页Journal of Audiology and Speech Pathology

摘　　要：目的　观察游泳锻炼对川芎嗪改善慢性低氧豚鼠耳蜗微循环的影响。方法　将33只豚鼠随机分成舱外正常对照组(A)与慢性低氧模型组(B)。4周后慢性低氧模型组又随机分为对照组(B1)、川芎嗪治疗组(B2 )、单独游泳组(B3 )和川芎嗪治疗+游泳锻炼组(B4)。豚鼠喂养到规定的时间后均用激光多普勒统计耳蜗血流量,螺旋韧带铺片光镜观察豚鼠血管纹毛细血管的形态及血管内红细胞计数,并对其结果进行统计学比较。结果　B2 和B4两组分别与B1组比较,耳蜗血流量和血管内红细胞计数有显著差异,且前两者耳蜗血管纹毛细血管丰富,血细胞分布均匀,未见明显的缺血及淤血区;B3 组与B1组、B4组与B2 组比较,有好转,但无显著性差异。结论　游泳锻炼可能促进慢性低氧环境下豚鼠耳蜗毛细血管的肿胀及红细胞淤滞现象的改善。Objective To explore the effect of swimming training on the microcirculations of cochlea in guinea pigs with tertram ethylpyrazine(TMP) treatment after chronic hypoxia.Methods 28 guinea pigs were divided into normal control group outside of cabin (A) and chronic hypoxia model group (B). After four weeks the model group were divided into the model control group (B 1),TMP treatment group (B 2),swimming training group(B 3) and swimming training with TMP treatment group (B 4).Until the given time,LDF was used to investigate the blood flow of every guinea pig's cochlea.The spiral ligament spreaded-slice optical lens was used to observe guinea pig's vascular veins, capillary appearance and RBC counts.Results There was significant difference in cochlear blood flow(CBF) and RBC counts between B 2,B 4 groups and B 1 group.CBF and RBC counts of B 3 group was improved comparing with B 1 gorup,so did that of B 4 group comparing with B 2.But no significant difference was found.Conclusion Swimming training can relieve the swelling on the thin blood vessel and improve the effect of TMP on the microcirculation in cochlea of guinea pigs under chronic hypoxia environment.

关 键 词：耳蜗 微循环 川芎嗪 游泳锻炼 

分 类 号：R764.35[医药卫生—耳鼻咽喉科]