液晶复合膜的表面形貌特征及其血液相容性研究  

Study on the External Shape Characteristic and the Blood Compatibility of the Liquid Crystal Composite Membranes

作　　者：屠美[1] 牟善松[1] 

机构地区：[1]暨南大学生物医学工程研究所,广东广州510632

出　　处：《中国医学物理学杂志》2005年第3期551-553,521,共4页Chinese Journal of Medical Physics

基　　金：国家自然科学基金资助项目(3037041x3)

摘　　要：目的:模仿生物膜的表面结构形态,制备液晶/聚氨酯复合膜,作为抗凝血生物材料;材料和方法:将胆甾醇液晶引入到聚合物中,制成液晶复合材料,利用偏光显微镜观察复合材料的表面形貌特征,并通过溶血率测试,动态凝血试验及血小板粘附试验探究液晶/PU复合膜的血液相溶性;结果:在聚合物基材中加入亲水性的胆甾醇液晶可使复合材料表面呈现有液晶微区的有序结构特征,复合膜表面的抗凝血性能提高;结论:胆甾醇液晶能明显改善材料的血液相容性,改善的程度与液晶的组成及复合膜中液晶的含量相关。Purpose: Imitating the surficial structure and shape of biologic membranes, the cholesteryl liquid crystal/PU composite membranes were prepared as anti-clotting biomaterials. Materials and methods: the cholesteryl liquid crystals were introduced into polymer to come into being composite materials. The surficial shape characteristic of the composite membranes were observed by optical polarization microscopy, and their blood compatibility were identified by measurement of the haemolysis ratio, the dynamic blood clotting test and the platelet adhesion test. Results: composite materials exhibited the characteristic of the ordered liquid crystal domain when introduced ordered and flowing cholesteryl liquid crystals into PU, and the anti-clotting properties of the one got improved. Conclusion: the cholesteryl liquid crystal could obviously improved the blood compatibility of raw materials, and the degree of improvement was related with the compose and content of cholesteryl liquid crystal.

关 键 词：表面形貌 复合膜 相容性研究 液晶 抗凝血生物材料 血小板粘附试验 复合材料 血液相溶性 抗凝血性能 血液相容性 胆甾醇 结构形态 微镜观察 凝血试验 结构特征 表面呈现 聚合物 生物膜 聚氨酯 溶血率 亲水性 

分 类 号：R318.08[医药卫生—生物医学工程] R361.3[医药卫生—基础医学]