HLA-DRB~*1201/~*1501与HBV感染不同状态的相关性  

Association between HLA-DRB1~*1201/~*1501 and different stages of HBV infection

作　　者：袁俊华[1] 崔萌[2] 孙成刚[1] 于会莉 

机构地区：[1]山东大学山东省立医院消化内科,山东济南250021 [2]济南市槐荫人民医院消化内科,山东济南250021 [3]淄博市桓台县田庄镇卫生院,山东淄博256402

出　　处：《山东大学学报（医学版）》2005年第5期428-431,共4页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨HBV感染的不同状态与HLA-DRB1等位基因之间的相关性。方法:采用聚合酶链反应/序列特异性引物技术(PCR/SSP)分别对慢性乙型肝炎组、HBV携带组、HBV感染后自然恢复组和正常对照组进行HLA-DRB1等位基因的检测。结果:HLA-DRB1觹1201/觹1501在慢性乙型肝炎组和HBV携带组出现的频率均明显高于正常对照组(均为P<0.01),HLA-DRB1觹1201在乙肝肝硬化患者、HLA-DRB1觹1501在原发性肝癌患者中出现的频率与正常对照组比较具有统计学意义(P<0.05,Pc<0.01)。结论:HLA-DRB1觹1201/觹1501可能是慢性乙型肝炎和HBV携带者的易感基因,而HLA-DRB1觹1201还可能是乙肝肝硬化的易感基因,HLA-DRB1觹1501可能是原发性肝癌的易感基因。Objective: To investigate the association between HLA-DRB1*1201 / *1501 and different stages of HBV infection. Methods: Polymerase chain reaction/sequence specific primer (PCR-SSP) technique was used to analyze HLA-DRB1 alleles in the following four groups: patients with chronic hepatitis B, carriers of HBV, spontaneous recoverers after HBV infection, and normal controls. Results: The frequencies of HLA-DRB1*1201 /*1501 in chronic hepatitis B and carriers of HBV were higher than those in normal controls (both P<0.01). The frequencies of HLA-DRB1*1201 in patients with liver cirrhosis due to HBV and HLA-DRB1*1501 in patients with primary liver neoplasm had statistically significant differences with those in normal controls(P<0.05 and Pc<0.01). Conclusions: The alleles of HLA-DRB1*1201 and HLA-DRB1*1501 are probably susceptive genes to the patients with chronic hepatitis B and the carriers with HBV, the former being probably susceptive to the liver cirrhosis due to HBV and the latter probably to the primary liver neoplasm.

关 键 词：肝炎 乙型 慢性 肝硬化 肝肿瘤 聚合酶链反应 

分 类 号：R512.62[医药卫生—内科学]