谷胱甘肽对镉金属硫蛋白肾毒性的影响  

Effects of glutathione against cadmium-metallothionein nephritoxicity

作　　者：欧钢卫[1] 钱民章[1] 葛正龙[1] 

机构地区：[1]遵义医学院生物化学教研室

出　　处：《遵义医学院学报》1994年第3期183-185,共3页Journal of Zunyi Medical University

基　　金：贵州省教委科研基金

摘　　要：本文研究了谷胱甘肽（GSH）对镉金属硫蛋白（CdMT）肾毒性作用的影响。结果发现，与单独给予CdMT比较，GSH能降低尿蛋白量和尿碱性磷酸酶（AKP）活性，并能促进尿Cd的排泄。肾组织形态学结果显示肾近曲小管损伤程度明显减轻。提示GSH对CdMT肾损伤具有保护作用。The effects of glutathione against nephrotoxicity induced by CdMT were studied in male Wistar rats; The results showed that GSH can decrease the urinary protein content and urinary al kaline phosphatase activity and prove the urinary cadndum excreation comparing with the rats treated only by OdMT significantly. Morphologically,the degree of the renal tubular damage was reduced. These findings demonstrate that GSH has the protective role against CdMT nephrotokici ty.

关 键 词：谷胱甘肽 镉金属硫蛋白 肾 大鼠 

分 类 号：R995[医药卫生—毒理学] R994.1[医药卫生—药学]