模拟高原低氧对不同性别新生大鼠下丘脑CRF和AVP水平的影响  

THE EFFECTS OF SIMULATED HYPOXIA ON THE DEVELO-PMENT OF HYPOTHALAMIC CRF AND AVP NEURONS IN POSTNATAL RATS

作　　者：杨生妹[1] 杜继曾[2] 

机构地区：[1]扬州大学生命科学与技术学院生物化学教研室,江苏扬州225009 [2]浙江大学生命科学学院神经生物学教研室,浙江杭州310027

出　　处：《中国应用生理学杂志》2005年第2期153-155,共3页Chinese Journal of Applied Physiology

摘　　要：目的:探讨高原低氧对雌雄新生大鼠下丘脑腺垂体肾上腺皮质轴中枢部位肽能神经元发育的影响。方法:在低压氧舱中模拟高海拔低氧,用放免法测定精氨酸加压素(AVP)和下丘脑促肾上腺皮质激素释放激素(CRF)含量。结果:无论是在2300m对照海拔,还是在5000m模拟海拔,雌雄生后大鼠具相同的发育模式。低氧下发育至21d时,CRF水平显著低于对照;相反,21d及28d时,低氧组AVP水平高于对照。结论:下丘脑CRF和AVP神经元间不同的发育模式可能与它们的功能及发育阶段特性相异有关。Aim: To investigate the influence of hypoxia on postnatal developing pattern of hypothalamic corticotropin releasing factor(CRF) and arginine vasopressin(AVP) in male and female neonatal rats. Methods: The hypoxia was simulated in hypobaric cabin. The content of AVP and CRF was assayed by RIA method. Results: It was showed the female rats had the similar developing process with male rats, either at 2 300 m or at 5 000 m altitude . When they developed at simulated 5 000 m altitude, the content of their hypothalamic CRF was lower than that of control rats on postnatal day 21, while the content of AVP was higher than control on day 21 and 28. Conclusion: Maybe the difference of the function between hypothalamic CRF and AVP or/and the incoherence of their developing stage contribute to their particular developing pattern at 5 000 m altitude.

关 键 词：模拟低氧 新生大鼠 下丘脑 CRF AVP 

分 类 号：R852.11[医药卫生—航空、航天与航海医学] R338.2[医药卫生—临床医学]