高胆固醇饲料对雄兔凝血和纤溶系统活性的影响  

EFFECTS OF CHOLESTEROL RICH DIET ON BLOOD COAGULATIVE AND FIBRINOLYTIC ACTIVITIES IN MALE RABBITS

作　　者：司全金[1] 李小鹰[1] 

机构地区：[1]解放军总医院老年心脏内科,北京100853

出　　处：《中国应用生理学杂志》2005年第2期224-226,共3页Chinese Journal of Applied Physiology

摘　　要：目的:探讨高胆固醇饲料喂养对兔血液凝血和纤溶系统活性的影响。方法:14只10～12周龄的健康雄性新西兰家兔,随机分为高胆固醇饲料喂养组(高胆固醇组)和普通饲料喂养组(对照组)。高胆固醇组以含1%胆固醇的饲料喂饲,每天100g,自由饮水,对照组给予不含胆固醇的普通饲料喂养,共喂养14周。所有雄兔均分别于高胆固醇饲料喂养前及不同饲料喂养后12周采耳缘静脉血分别测定血脂水平变化及血液凝血和纤溶系统活性变化。结果:①与对照组及基础值相比,高胆固醇组雄兔血中的甘油三酯、总胆固醇、低密度脂蛋白、脂蛋白(a)、载脂蛋白B水平显著升高;②高胆固醇组雄兔血小板活性显著增强、凝血酶原时间及活化部分凝血酶时间缩短、纤维蛋白原含量增加;③高胆固醇组纤溶酶原活性、α2抗纤溶酶活性较普通组增强。结论:高胆固醇饮食不仅能直接导致高脂血症的形成,还可显著增强血液凝血活性和抑制血液纤溶活性,促进动脉粥样硬化的发生发展。Aim: To explore the effects of cholesterol rich diet on the activities of blood coagulative and fibrinolytic systems in male rabbits. Methods: 14 male New Zealand white rabbits were randomized to cholesterol rich diet(CRD) group and common diet(control) group. Rabbits in CRD group were fed with 1% cholesterol embedded diet and those in the control group were fed with common diet. Levels of blood TG,TC, LDL,HDL,Lp(a),apoA1,apoB,FIB,D-dimers and FDP, PT and APTT, activity of ADP,AT-Ⅲ, PLG and α_2-PI were tested in all rabbits before given cholesterol rich diet and after 12 weeks' feeding with different kinds of diet. Results: Levels of blood TG,TC,LDL,HDL,Lp(a),apoA1,apoB,FIB,D-dimers in CRD group were all elevated significantly compared with those in the control group and the baseline levels. PT and APTT were shortened, ADP,PLG and α_2-PI activity were increased in CRD group. Conclusion: Cholesterol rich diet not only is the direct cause of hyperlipidemia but also can increase the coagulative activity and inhibit the fibrinolytic activity and promoting the evolution of arteriosclerosis.

关 键 词：血脂 凝血 纤溶 饮食 胆固醇 

分 类 号：R541[医药卫生—心血管疾病]