家兔实验性膜性肾小球肾炎的光镜与电镜图象立体学定量分析(英文)  

STEREOLOGICAL QUANTITATIVE ANALYSIS OF LM AND EM IMAGES ON MEMBRANOUS GLOMERULONEPHRITIS(MGN)OF RABBITS

作　　者：马跃荣[1] 胡礼振[1] 吕廉捷[1] 王祖乾[1] 谢永康[1] 

机构地区：[1]泸州医学院病理学教研室,646000

出　　处：《泸州医学院学报》1994年第2期111-115,共5页Journal of Luzhou Medical College

摘　　要：采用Border膜性肾小球肾炎模型作为实验组,另设正常对照组,从光镜与电镜图象立体学定量角度观察分析膜性肾小球肾炎的病理变化。结果表明:实验组上皮电子致密沉积物及肾小球各定量参数与对照组比较有显著和极显著差异性(P<0.05和P<0.001)。实验组第8周新月体(或环状体)的体密度为17.39％。对照组与实验组基底膜厚度分别为168nm和627nm(P<0.001)。MGN Model in rabbits was established according to Border's method. The pathological changes of MGN were analyzed through stereological quantitative technique under LM and EM. Results indicated that the quantitative parameters of subepithelial electron dense deposits and the glomeruli in the experimental group were remarkably different statistically from those of the control group (P<0. 05 or P <0.001). In the experimental group, the volume density of glomerular crescent or circumferential corpuscle was 17. 39% at the 8th week of the experiment. The thickness of glomerular basement membrane (GBM) was 168 nm in the control group and 627 nm in the experimental group (F<0. 001).

关 键 词：肾小球肾炎 立体学定量分析 光镜 电镜 病理学 

分 类 号：R692.602[医药卫生—泌尿科学]