鼻息肉组织中Fas和FasL的表达及其意义  

The expression and significance of Fas/FasL in nasal polyps tissue

作　　者：李钦[1] 明伟[2] 张红萍[2] 陈雪梅[2] 剪京芬[2] 张大良[2] 

机构地区：[1]临沂市人民医院耳鼻咽喉科,山东临沂276003 [2]山东大学第二医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉科杂志》2005年第11期492-494,共3页Journal of Clinical Otorhinolaryngology

摘　　要：目的:通过对鼻息肉组织中Fas和FasL因子的检测,以探讨Fas和FasL因子在鼻息肉发生,发展过程中的介导及调控作用。方法:应用逆转录聚合酶链反应(RTPCR)方法,检测40例鼻息肉组织匀浆及5例正常鼻黏膜中Fas和FasL因子的基因表达。结果:40例鼻息肉组织中FasL呈强势表达,Fas呈弱势表达,其相对系数的平均指数分别为:(0.62±0.74)、(0.14±0.25),与正常对照组相比差别有统计学意义(均P<0.05)。Fas在正常鼻腔黏膜上皮细胞中的表达阳性率显著大于鼻息肉组织,FasL不表达。结论在鼻息肉的发生、发展过程中存在着Fas的表达下调和FasL的上调,鼻息肉上皮细胞逃避了Fas和FasL系统介导的细胞凋亡而过度增殖。Objective:To explore the induction and control effect of Fas/FasL system in the occurrence and evolution of nasal polyps tissue.Method:Nasal polyps samples of 40 cases and 5 healthy adults were examined for the genic expressions of factors Fas and FasL by using the method of reverse transcription polymerase chain reaction (RT-PCR).Result:The results indicated that the expressions of FasL in nasal polyps was high,and the expressions of Fas was low.The average index of correlative quotiety was(0.62±0.74),(0.14±0.25).The positive percentage in epithelial cells of normal nasal mucosa was significant higher than that of nasal polyps. There was no expressions of FasL in normal nasal mucosa, but in nasal polyps there were different degree expressions, mostly in epithelial cells.Conclusion:The downwards expression of Fas and the upwards expression of FasL in nasal polyps may inhibit the cellular apoptosis and the enhanced hyperplasia.

关 键 词：FAS/FASL 基因表达 鼻息肉 细胞凋亡 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]