卡介苗多糖核酸与结核菌素皮试阳转的相关性研究  

Correlations between BCG-PSN and tuberculin responses

作　　者：杨玉成[1] 洪苏玲[1] 黄江菊[1] 王祎琴[1] 孙荣[1] 钱迪[1] 董小琴[1] 何芸[1] 

机构地区：[1]重庆医科大学附属第一医院耳鼻咽喉科,重庆400016

出　　处：《临床耳鼻咽喉科杂志》2005年第11期498-500,共3页Journal of Clinical Otorhinolaryngology

基　　金：国家"十五"科技攻关基金资助项目(No:2004BA720A1902)

摘　　要：目的:探讨卡介苗多糖核酸(BCGPSN)诱导变应性鼻炎患者结核菌素皮试(PPD)阳转情况及其治疗变应性鼻炎的相关机制。方法:将60例变应性鼻炎患者,随机分为BCGPSN治疗组和口服息斯敏组,各30例。正常对照组20例。应用酶联免疫吸附试验和UniCAP系统检测治疗前后血清嗜酸粒细胞阳离子蛋白(ECP)、血清总IgE(tIgE)水平,同时观察PPD。结果:BCGPSN治疗组治疗后,ECP、tIgE明显低于治疗前,差异有统计学意义(P<0.01),PPD阳转率为37.5%,与息斯敏组比较差异有统计学意义(P<0.01)。结论:BCGPSN可调节变应性鼻炎患者的免疫失衡,促进Th1细胞功能,减轻变应性鼻炎的发作。Objective:To investigate the correlations between tuberculin responses and allergic rhinitis treated by BCG-PSN.Method:A total 60 patients with allergic rhinitis were randomly divided into BCG-PSN treated group and control group.All patients were given purified protein derivate (PPD), and PPD induration were recorded after 72 h, also the eosinophil cationic protein(ECP) and total IgE(TIgE) in serum were assayed with Pharmacia UniCAP System.Result:ECP and tIgE levels of patients treated by BCG-PSN were significantly lower than before treatment(P<0.01).37.5% patients who had negative reaction had induration after treatment using BCG-PSN.Conclusion:These results indicate that exposure BCG-PSN can correct the imbalance state of Th1 and Th2 cytokines and inhibit allergic airway inflammation and control allergic rhinitis.

关 键 词：鼻炎 变应性 卡介苗多糖核酸 嗜酸粒细胞阳离子蛋白 结核菌素皮试 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]