更昔洛韦联合西咪替丁治疗婴幼儿轮状病毒肠炎临床观察  

Ganciclovir and cimetidine therapy for infants with rotavirus enteritis

作　　者：陈淑君[1] 柳锡永[1] 朱笑频[1] 

机构地区：[1]浙江省义乌市中心医院,浙江义乌322000

出　　处：《儿科药学杂志》2005年第3期44-45,共2页Journal of Pediatric Pharmacy

摘　　要：目的:探讨更昔洛韦与西咪替丁联合治疗婴幼儿轮状病毒肠炎的效果。方法:88例轮状病毒肠炎患儿随机分为更昔洛韦组、更昔洛韦+西咪替丁组、对照组三组。结果:治疗3d总有效率更昔洛韦组、更昔洛韦+西咪替丁组、对照组分别为91.7%、92.9%、41.7%,差异有显著意义(χ2=26.33,P<0.01)。组间比较显示,更昔洛韦组、更昔洛韦+西咪替丁组总有效率明显高于对照组(χ2=17.73、15.90,P<0.01);更昔洛韦+西咪替丁组总有效率与更昔洛韦组比较差异无显著意义(χ2=0.09,P>0.05),但显效率(64.3%)明显高于更昔洛韦组的36.1%(χ2=5.01,P<0.05)。结论:更昔洛韦与西咪替丁联合治疗婴幼儿轮状病毒肠炎疗效较好,值得临床应用。Objective: To explore the effect of ganciclovir and cimetidine therapy on infants with rotavirus enteritis. Methods: 88 infants with rotavirus enteritis were randomly divided into ganciclovir group, ganciclovir + cimetidine group and control group. Results: The total effective rates of ganciclovir group, ganciclovir +cimetidine group and control group in first 3 days of the treatment were 91.7%, 92.9% and 41.7% ( χ2 = 26.33, P < 0.01), respectively. The total effective rates of ganciclovir group, ganciclovir + cimetidine group were significantly higher than that of control group ( χ2 = 17.73 and 15.90, P < 0.01). There was no significant difference between ganciclovir+cimetidine group and ganciclovir group ( χ2 = 0.09, P > 0.05), but the notable effective rates of the former group were significantly higher than that of ganciclovir group (64.3% Vs 36.1%, χ2 = 5.01, P < 0.05). Conclusion: Ganciclovir and cimetidine in treating infants with rotavirus enteritis is effective.

关 键 词：更昔洛韦 西咪替丁 轮状病毒肠炎 

分 类 号：R978.7[医药卫生—药品]