3-氯-4-三氟甲氧基苯甲腈的合成  

SYNTHESIS OF 3-CHLORO-4-TRIFLUOROMETHOXY BENZONITRILE

作　　者：赵昊昱[1] 

机构地区：[1]常州工程职业技术学院化工系,江苏常州213164

出　　处：《精细石油化工》2005年第3期52-54,共3页Speciality Petrochemicals

摘　　要：以3-氯-4-三氟甲氧基苯胺为原料,经重氮化、甲醛肟化、水解和腈化反应得到纯度≥99.2%(GC)的3-氯-4-三氟甲氧基苯甲腈,总收率为31.5%。中间体及产物结构通过 IR 及元素分析验证。产物色泽好,腈化反应的溶剂可回收使用3次。The 3-chloro-4-trifluoromethoxy benzonitrile was synthesized from 3-chloro-4-trifluorome- thoxy aniline by diazotization,formaldoximation,hydrolysis and cyanation.The overall yield was 31. 5% and the purity was ≥99.2%(GC).The structure of the intermediate and the product were con- firmed by IR and elementary analysis.The color of the product is excellent.The menstruum of cyana- tion could be recovered and reused for 3 times.

关 键 词：苯甲腈 三氟 合成 氯 甲氧基苯胺 元素分析 产物结构 回收使用 重氮化 总收率 中间体 反应 腈化 甲醛 水解 溶剂 

分 类 号：TQ246.7[化学工程—有机化工] TQ245.12