中国人群补体C_1R的遗传多态性  

GENETIC POLYMORPHISM OF C_1R SUBCOMPONENT OF THE FIRST COMPLEMENT COMPONENT IN CHINESE POPULATION

作　　者：铁坚[1] 王秀玲[1] 贾静涛[1] 

机构地区：[1]中国医科大学法医血清学教研室,沈阳110001

出　　处：《中国法医学杂志》1994年第3期153-155,共3页Chinese Journal of Forensic Medicine

摘　　要：采用聚丙烯酰胺等电聚焦电泳，结合免疫印迹技术，对中国辽宁地区360名无关个体的补体C1R遗传多态性进行了研究。共检出6种常见表现型和4种变异型。基因频率C1R*1=0．5181，C1R*2=0．3291，C1R*3=0．1472，CIR*R=0．0056，分布符合Hardy-Weinberg法则。C1R的血型鉴别机率（DP值）为0．7694，是一种具有高度鉴别能力的血清多态性遗传标记。Genetic polymorphism of the C1R subcomponent of human first complement component was in-vestigated in 360 unrelated Chinese individuals using isoelectric focusing followed by immunoblotting.Six common and four rare were detected. The allele frequencies were as follows: C1R * 1 = 0. 5181,C1R × 2=0. 5291,C1R * 3= 0. 1472 and C1R * R(C1R * 5,C1R * 6,C1R * 12 and C1R * 13) = 0.0056. The distribution of allotypes fitted the Hardy-Weinberg equilibrium. This complemlement sys-tem is a useful genetic marker for anthropological studies and forensic science practice.

关 键 词：补体C1R 中国人群 遗传多态性 

分 类 号：R392.7[医药卫生—免疫学]