初乳素预防化学性肝损伤的实验研究  

Study of colostrin on mice's chemical liver injury

作　　者：江海涛[1] 吴京燕[1,2] 程光宇[1,2] 侯玉如[1] 余多慰[1] 

机构地区：[1]南京师范大学生命科学学院 [2]江苏吴中大自然生物生物工程有限责任公司,江苏南京210097

出　　处：《中国乳品工业》2005年第5期12-14,共3页China Dairy Industry

摘　　要：研究了初乳素对化学性肝损伤的保护作用。将小鼠随机分为5组,低剂量组和高剂量组分别灌喂(0.2g/kg和0.6g/kg)初乳素,阳性对照组灌喂联苯双酯(0.2g/kg),正常对照组和模型组灌喂等量的蒸馏水,30d后,用体积分数为1%的CCl4造模,处死小鼠。测定小鼠血清AST和ALT酶活性、血液及肝脏中SOD活性、MDA含量,并观察肝细胞形态结构的变化。结果表明,初乳素能降低血清AST和ALT的酶活性、降低MDA含量、增强SOD的活性,并能有效地减轻肝细胞的损伤。初乳素具有预防化学性肝损伤的保护作用。This paper mainly studies the protective effect of colostrin on mice's chemical liver injury .:Mice were randomly devided into 5 groups ,low dose of group and high dose of group were given ig 0.2g/kg.d and 0.6g/kg.d respectively.Positive group were given ig 0.2g/kg.d bifendate .Normal group and model group were given ig distilled water .After 30 days ,mice were treated with 1% CCl4 and then were killed. AST, ALT of serum in mice were measured ,SOD and MDA of blood and liver were determined ,liver pathological changes were observed. Colostrin can significantly inhibit the elevation of AST,ALT of serum in mice ,can increase the activity of SOD and decrease the content of MDA , meanwhile colostrin can relieve the hepatic injury .Colostrin has the protective effect on mice's chemical liver injury induced by 1% CCl4.

关 键 词：活性初乳素 四氯化碳 化学性肝损伤 

分 类 号：TS252.1[轻工技术与工程—农产品加工及贮藏工程]