抗癌药物卡莫氟合成方法的改进  

Improved Method for Synthesizing Anticancer Medicine Carmofur

作　　者：王玉民[1] 曹晓群[1] 张昌军[1] 朱焰[1] 

机构地区：[1]泰山医学院化学化工学院,山东泰安271000

出　　处：《精细与专用化学品》2005年第10期11-13,共3页Fine and Specialty Chemicals

摘　　要：以正庚酸、氯化亚砜和叠氮化钠为原料,通过酰化、库尔提斯重排反应制备异氰酸己酯,然后在4(N,N二乙氨基)吡啶催化下与5氟尿嘧啶缩合得到抗癌药物卡莫氟,总收率75.4%。并用元素分析、红外光谱和1HNMR对其结构进行了表征。Using n-heptanoic acid, thionyl chloride and sodium azide as raw materials, the hexyl isocyanate was prepared via acylation and Curtius conversion. And then the title compound was synthesized through reacting of 5-fluorouracil with hexyl isocyanate in the presence of 4-(N,N-diethylamino)pyridine as catalyst. The overall yield of 75.4% is achieved.Meanwhile,its structure was characterized by elementary analysis, IR and 1H NMR.

关 键 词：抗癌药物 合成方法 5-氟尿嘧啶 叠氮化钠 氯化亚砜 重排反应 二乙氨基 元素分析 红外光谱 异氰酸 总收率 ^1H NMR 酰化 吡啶 酯 

分 类 号：TQ463[化学工程—制药化工]