Maximal sequence length of exact match between members from a gene family during early evolution  

作　　者：温晓 郭兴益 樊龙江 

机构地区：[1]Institute of Crop Science, Zhejiang University, Hangzhou 310029, China [2]Institute of Bioinformatics/IBM Biocomputational Lab, Zhejiang University, Hangzhou 310029, China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2005年第6期470-476,共7页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project supported by the National Natural Science Foundation of China (Grant Nos. 30270810, 90208022 and 30471067) and IBM Shared University Research (Life Science), China

摘　　要：Mutation (substitution, deletion, insertion, etc.) in nucleotide acid causes the maximal sequence lengths of exact match (MALE) between paralogous members from a duplicate event to become shorter during evolution. In this work, MALE changes between members of 26 gene families from four representative species (Arabidopsis thaliana, Oryza sativa, Mus mus- culus and Homo sapiens) were investigated. Comparative study of paralogous’ MALE and amino acid substitution rate (dA<0.5) indicated that a close relationship existed between them. The results suggested that MALE could be a sound evolutionary scale for the divergent time for paralogous genes during their early evolution. A reference table between MALE and divergent time for the four species was set up, which would be useful widely, for large-scale genome alignment and comparison. As an example, de- tection of large-scale duplication events of rice genome based on the table was illustrated.Mutation (substitution, deletion, insertion, etc.) in nucleotide acid causes the maximal sequence lengths of exact match (MALE) between paralogous members from a duplicate event to become shorter during evolution. In this work, MALE changes between members of 26 gene families from four representative species (Arabidopsis thaliana, Oryza sativa, Mus mus- culus and Homo sapiens) were investigated. Comparative study of paralogous’ MALE and amino acid substitution rate (dA<0.5) indicated that a close relationship existed between them. The results suggested that MALE could be a sound evolutionary scale for the divergent time for paralogous genes during their early evolution. A reference table between MALE and divergent time for the four species was set up, which would be useful widely, for large-scale genome alignment and comparison. As an example, de- tection of large-scale duplication events of rice genome based on the table was illustrated.

关 键 词：Maximal length of exact match (MALE) Divergent time Gene family Minimal length of exact match (MILE) Genome alignment 

分 类 号：Q754[生物学—分子生物学]