L-丙氨酸乙酯还原反应的研究  

Study on the Reduction of Ethyl L-Alaninate

作　　者：闫喜龙[1] 郭文琳[1] 李阳[1] 白国义[1] 李乐平[1] 陈立功[1] 

机构地区：[1]天津大学化工学院,天津300072

出　　处：《化学反应工程与工艺》2005年第2期186-190,共5页Chemical Reaction Engineering and Technology

摘　　要：对L-丙氨酸乙醣的还原方法进行了研究,采用的还原剂有NaBH4,KBH4,KBH4复合还原剂,金属钠,BER树脂,铜铬氧化物,骨架镍等。NaBH4的还原效果优于KBH4。考察了NaBH4还原L-丙氨酸乙酯的影响因素,优化最佳工艺条件为n(NaBH4): n(L-丙氨酸乙酯)投料比2:1,用水作溶剂,室温下反应4h,收率为84.7%。添加ZnCl2,AlCl3和LiCl能提高KBH4还原活性,其中ZnCl2的效果较好,收率可达60.2%。By reducer including NaBH4, KBH4, sodium, BER resin, modified KBH4, copper chromic oxide, Raney Ni, reduction of ethyl L-alaninate was studied. It was found that reduction yield of NaBH4 was better than KBH4 under reaction conditions n(NaBH4):n(Ethyl L-Alaninate) 2:1, water as solvent for 4 h at room temperature, yield 84.7%. The reduction activity of KBH4 increased by adding ZnCl2, AlCl3 and LiCl, in which that of adding ZnCl2 was better in reduction yield of 60.2%.

关 键 词：L-丙氨酸乙酯 还原反应 L-丙氨酸 (S)-2-氨基丙醇 手性氨基醇类化合物 

分 类 号：TQ226.34[化学工程—有机化工]