无症状HBV携带者血清HBVDNA水平与肝组织炎症活动度的关系  

Relationship between serum HBV DNA level and the hepatic inflammation grading in asymptomatic HBV carriers

作　　者：陈国良[1] 吴丽[1] 

机构地区：[1]福建省厦门市中医院肝病中心,361001

出　　处：《实用肝脏病杂志》2005年第3期132-133,共2页Journal of Practical Hepatology

摘　　要：目的探讨无症状HBV携带者(AsC)肝脏病理损害程度与血清HBVDNA水平的关系。方法对139例AsC于超声引导下采用美国生产的DARD自动活检枪经皮肝穿刺行病理学检查;HBVDNA用PCR测定。结果139例AsC中G1者94例,G2者26例,G3者19例,无G0和G4者;血清HBVDNA水平与肝组织炎症活动度间无显著性差异(P>0.05);HBeAg阴性组G3者所占比例大于HBeAg(+)组(P=0.019)。结论AsC肝脏均有不同程度损害,其损害程度与HBVDNA水平无相关性。Objective To research the relationship between serum HBV DNA level and the histological damage grading in the asymptomatic HBV carriers.Methods 139 asymptomatic HBV carriers had liver biopsy and liver pathological examinations;their serm HBV DNA was examined by PCR.Results There were 94 in grade one,26 in grade two and 19 in grade three.There was no relationship between the HBV DNA level and the hepatic inflammation grading ( P >0.05).The individuals with negative HBeAg had higher proportion of grade three in with positive HBeAg ( P =0.019).Conclusion There are various damage in the livers of asymptomatic HBV carriers,and the damage grading has no relations with the level of HBV DNA.

关 键 词：无症状HBV携带者 DNA水平 血清HBV 肝组织炎症活动度 HBeAg(+) HBeAg阴性 病理损害程度 病理学检查 经皮肝穿刺 自动活检枪 超声引导下 PCR测定 显著性差异 AsC 不同程度 相关性 肝脏 G3 

分 类 号：R512.62[医药卫生—内科学]