糖尿病病人FPG水平变化与hs-TSH的相关性研究  

Study on Diabetes Patient FPG Horizontal Change and Dependence of Hs-TSH

作　　者：唐浩熙[1] 李介华[1] 李绍清[1] 李冬秀[1] 岑欢[1] 

机构地区：[1]暨南大学医学院第五附属医院暨广东省清远市人民医院,广东清远511500

出　　处：《现代检验医学杂志》2005年第3期29-31,共3页Journal of Modern Laboratory Medicine

基　　金：广东省清远市科技局计划项目(No:20041721)。

摘　　要：目的观察糖尿病病人的空腹血糖(FPG)水平变化与超敏促甲状腺激素(hs-TSH)的相关性,评估糖尿病人的病情发展程度.方法正常对照组50人.糖尿病组:住院病人100例,男43例,女57例,平均年龄57 y.将FPG浓度在7～10mmol/L之间的65人编为A组,FPG>10 mmol/L的35人编为B组.在100例糖尿病人中无合并症者67人编为C组,有急性合并症者33人编为D组.正常对照组和糖尿病组病人均于清晨空腹采静脉血3 ml,分离血清,FPG采用全自动生化分析仪检测,hs-TSH采用化学发光免疫分析法(CLIA)定量检测.结果A组hs-TSH浓度为1.03±0.25 mIU/L,B组hs-TSH浓度为0.70±0.41 mIU/L,C组hs-TSH浓度为0.97±0.32 mIU/L,D组hs-TSH浓度为0.47±0.19 mIU/L.A组hs-TSH浓度与B组比较P=0.0006,有统计学意义(P＜0.001).对糖尿病组进行FPG和hs-TSH的相关性统计,其相关系数r=-0.1835.因此,FPG浓度与hs-TSH浓度呈负相关,主要是促甲状腺素释放激素(TRH)较少,从而使得hs-TSH呈低弱反应.当糖尿病人的hs-TSH浓度为0.47±0.19 mIU/L时有发生急性合并症的可能.C组与D组的hs-TSH浓度比较P=0.000 1,有统计学意义(P＜0.001).结论糖尿病患者hs-TSH浓度随FPG浓度的上升而下降,两者之间呈负相关.有急性合并症时hs-TSH浓度比无合并症组下降更明显,hs-TSH对糖尿病产生合并症有预测作用.Objective Observe the horizontal change and ultra quick dependence of hypersensitivity thyroid stimulating hormone(hs-TSH)of fasting plasma glucose(FPG) of the diabetes patient,contribute to assessing the diabetes patient's condition development degree.Methods Normal group 50 people.The diabetes group:100 people of hospital ization,43 men,57 women,average for 57 years old.Grouped FPG into for A grouop by density 65 people among 7～10 mmol/L;35 people(FPG>10 mmol/L)were grouped into for B group.Persons who didn't amalgamate disease 67 people was grouped into for C group, 33 persons who amalgamated acute disease were grouped into for D group,among 100 diabetes patients.They were adopted vein blood 3ml on an empty stomach in early morning normally,separating the serum.FPG was adopted the full-automatic biochemical analysis instrument to measure,hs-TSH was measured by the means of chemiluminescence immunoassay(CLIA).Results The density of group A hs-TSH was 1.03±0.25 mIU/L,the density of group B hs-TSH was 0.70±0.41 mIU/L,the density of group C hs-TSH was 0.97±0.32 mIU/L,the density of group D hs-TSH was 0.47±0.19 mIU/L.The density of group A hs-TSH compared with B, P=0.000 6,there was statistical meaning(P<0.001).Carried on dependence statistics of FPG and hs-TSH to the diabetes group,its coefficient correlation r was -0 .183 5.So,FPG density and hs-TSH density were not presented relevantly,mainly urged the thyroxine to releaseless hormone(TRH),thus made hs-TSH present the low weak response.Hs-TSH density of acting as the diabetes patient was 0.47±0.19 mIU/L.That was possible to shut and amalgamate disease acutedly hour.Group C compared with hs-TSH density of group D P=0.000 1,there was statistical meaning(P<0.001).Conclusion The diabetic hs-TSH density drops with rising of FPG density,presents and shoulders relevantly between the two.Hs-TSH density amalgamate acute disease group drop obviously,the measurement of hs-TSH have function of predictiong amalgamated disease of diabetes.

关 键 词：糖尿病 空腹血糖 超敏促甲状腺激素 促甲状腺素释放激素 相关性 

分 类 号：R587.1[医药卫生—内分泌] R446.112[医药卫生—内科学]