阿魏酸钠治疗糖尿病肾病的初步临床观察  

Preliminary Clinical Observation on Effect of Soduim Ferulate in Treating Diabetic Nephropathy

作　　者：郑凤鸣[1] 任跃忠[1] 赵同峰[1] 

机构地区：[1]浙江大学医学院附属二院内分泌科,杭州310009

出　　处：《中国中西医结合杂志》2005年第5期419-421,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的探讨阿魏酸钠(sodiumferulate,SF)对糖尿病肾病(diabeticnephropathy,DN)的影响。方法早期DN 48例和临床DN 54例,随机分为常规治疗组和阿魏酸钠治疗组,测定尿白蛋白排泄率(urinaryalbuminexcretionrates,UAER)、血浆内皮素(serumendothelin ,ET)、血尿素氮(bloodureanitrogen ,BUN)、血清肌酐(serumcreatinine ,SCr)和空腹血糖(fastingbloodglucose ,FBG) ,比较两组效果。结果治疗4周后,阿魏酸钠治疗组早期DN和临床DN治疗后UAER、BUN和血ET水平均显著下降(P <0. 0 5,P <0 . 0 1) ,而常规治疗组UAER、BUN和血ET水平治疗前后差异无显著性。结论阿魏酸钠能降低DN患者UAER和BUN ,其机制可能与其减少ET的生成或拮抗ET与其受体结合有关。ObjectiveTo investigate the effect of sodium ferulate (SF) on diabetic nephropathy (DN). MethodsForty-eight DN patients of early stage and 54 DN patients of clinical stage were randomly divided into two groups, the conventional treatment group and the SF treatment group. Indexes, including urinary albumin excretion rate (UAER), serum endothelin (ET), blood urea nitrogen (BUN), serum creatinine (Scr) and fasting blood glucose (FBG) were observed. ResultsThe levels of UAER, BUN and ET were decreased in all DN patients, either early stage or clinical stage, after treated with SF for 4 weeks (P<0.05, P<0.01), but changed insignificantly in those treated with conventional treatment. ConclusionSF can decrease the levels of UAER and BUN in DN patients, the mechanism may relate with the decreasing of ET production and antagonizing to the binding of ET with its receptors.

关 键 词：阿魏酸钠 糖尿病肾病 临床观察 尿白蛋白排泄率 ALBUMIN 初步 UAER 血浆内皮素 blood 治疗组 BUN 血尿素氮 urea 血清肌酐 空腹血糖 0.05 治疗前后 ET水平 受体结合 治疗后 DN 显著性 早期 

分 类 号：R587.2[医药卫生—内分泌]