Fas抗原在肠癌组织中的表达  

Fas antigen in tissue of colorectal carcinoma and its clinical significance

作　　者：吴潇 

机构地区：[1]桐乡市人民医院检验科,浙江桐乡314500

出　　处：《检验医学》2005年第3期260-261,共2页Laboratory Medicine

摘　　要：目的　研究Fas抗原在肠癌组织中的表达及意义。方法　采用双抗体酶联免疫吸附试验(ELISA)检测52例肠癌及相应的正常组织Fas抗原。结果　正常大肠组织Fas水平[ (2. 131±1. 523)pg/mg蛋白]明显高于大肠癌组织[ (0. 752±0. 168)pg/mg蛋白,P<0. 05],Fas抗原水平与癌转移相关(P<0. 05),但与癌细胞分化无关(P>0. 05)。结论　Fas反映了肿瘤的增殖和转移情况,提示Fas可抑制免疫功能和肿瘤细胞的凋亡。Objective To study the significance of Fas expression in colorectal carcinoma. Methods Fas level was tested in 52 cases of tissue of colorectal cancer and its corresponding normal colorectal tissue using double antibody (sandwich) ELISA. Results Fas levels of normal colorectal tissue [(2.131±1.523) pg/mg protein] were significantly higher than those of colorectal cancer tissue [(0.752±0.168) pg/mg protein,P<0.05]. Fas level was significantly correlated with lymph node metastasis, and not correlated with the histopathology type (P>0.05). Conclusions Fas levels reflected indirectly situation of proliferation and metastases of the tumor. Fas may inhibit the patients' immune function and tumor cells apoptosis.

关 键 词：FAS抗原 酶联免疫吸附试验(ELISA) 抑制免疫功能 大肠癌组织 癌细胞分化 正常组织 大肠组织 抗原水平 肿瘤细胞 g蛋白 表达及 双抗体 癌转移 

分 类 号：R392.11[医药卫生—免疫学] R512.6[医药卫生—基础医学]