慢性肺源性心脏病患者血浆神经降压素、神经肽Y的研究  

Study of plasma neurotensin and neuropeptide Y levels in patients with chronic pulmonary heart disease

作　　者：苏伟青[1] 余泽琪 沈如晖 李树裕[1] 宁晓明[1] 李少兰[1] 

机构地区：[1]廉江市人民医院心内科,广东廉江524400

出　　处：《临床荟萃》2005年第11期615-617,共3页Clinical Focus

摘　　要：目的研究慢性肺源性心脏病(肺心病)患者发病不同时期血浆神经降压素(NT)、神经肽Y(NPY)水平的变化,探讨其与慢性肺心病发病过程的关系。方法采用放射免疫方法(RIA)测定慢性肺心病急性加重期、稳定期各40例血浆中NT、NPY浓度变化,并选择40例健康者作为对照组。结果慢性肺心病急性加重期NT、NPY水平明显高于对照组[NT(149±31)ng/Lvs(59±20)ng/L,P<0.01;NPY(253±75)ng/Lvs(103±18)ng/L,P<0.01],慢性肺心病稳定期NT[(63±24)ng/L]、NPY[(98±20)ng/L]水平与对照组差异无统计学意义(P>0.05)。结论慢性肺心病急性加重期NT、NPY水平明显升高,提示NT、NPY参与了慢性肺源性心脏病的病理生理过程。Objective To study the plasma levels of neurotensin(NT) and neuropeptide Y(NPY) in patients with chronic pulmonary heart disease(CPHD). Methods Forty patients whth CPHD during acute phase,forty patients with CPHD during stable phase and forty healthy subjects were included.Plasma NT and NPY were measured by radioimmunoussay(RIA). Results Plasma NT and NPY levels in acute phase CPHD were significantly higher than those in healthy subjects[NT(149±31) ng/L vs (59±20) ng/L,P< 0.01;NPY(253±75) ng/L vs (103±18) ng/L,P< 0.01], and it had no significance during stable phase[NT(63±24) ng/L vs (59±20) ng/L,P> 0.05;NPY(98±20) ng/L vs (103±18) ng/L,P> 0.05]). Conclusion Elevated levels of plasma NT and NPY were seen in CPHD during acute phase ,which suggests that NT and NPY might take part in the pathophysical progression of CPHD.

关 键 词：肺心病 神经降压素 神经肽Y 

分 类 号：R541.5[医药卫生—心血管疾病]