叶酸偶联米托蒽醌白蛋白纳米粒的制备及体外性质研究  

Studies on preparation of folate-conjugated mitoxantrone-loaded albumin nanoparticles and its property in vitro

作　　者：张良珂[1] 侯世祥[2] 卢懿[2] 宋相容[2] 

机构地区：[1]重庆医科大学药学系,重庆400016 [2]四川大学华西药学院药剂教研室,四川成都610041

出　　处：《中国药学杂志》2005年第10期763-765,共3页Chinese Pharmaceutical Journal

基　　金：高等学校博士学科点专项科研基金资助(20020610092)重庆医科大学科研启动基金(B10001)

摘　　要：目的研究叶酸偶联米托蒽醌白蛋白纳米粒的制备工艺及体外性质。方法考察了pH值对包封率的影响及包封率与载药量之间的关系。并考察了不同量交联剂对纳米粒释药速度的影响。结果叶酸偶联米托蒽醌白蛋白纳米粒包封率为(96.55±0.96)%,载药量为(9.66±0.10)%。在加入了不同量的固化剂后,可得到释放速度不同的叶酸偶联米托蒽醌白蛋白纳米粒。结论优化了叶酸偶联米托蒽醌白蛋白纳米粒的制备工艺。OBJECTIVE: To study the preparation of folate-conjugated mitoxantrone-loaded albumin nanoparticles (MTO-BSANP-folate) and its property in vitro. METHODS: The influence of pH on embedding ratio and the relationship between embedding ratio and drug loading was evaluated. The release rate of MTO-BSANP-folate influenced by the addition of cross-linking agent was also investigated. RESULTS: The encapsulation ratio of MTO-BSANP-folate was (96.55 ± 0.96)% and the drug loading was (9.66 ± 0.10)%. MTO-BSANP-folate with different drug releasing rate were acquired after the addition of different quantity of cross-linking agent. CONCLUSION: The preparation method of MTO-BSANP-folate was optimized.

关 键 词：叶酸 米托蒽醌 白蛋白纳米粒 制备 

分 类 号：R943.3[医药卫生—药剂学]