异甘草酸镁注射液人体内药动学研究  

Pharmacokinetics of intravenous magnesium isoglycyrrhizinate in human

作　　者：沈金芳[1] 逄晓云[1] 孙黎[1] 

机构地区：[1]上海第二医科大学附属仁济医院临床药学研究室,上海200001

出　　处：《中国药学杂志》2005年第10期769-771,共3页Chinese Pharmaceutical Journal

摘　　要：目的研究异甘草酸镁的血药浓度测定方法及其在人体内的药动学。方法10名健康志愿者,单剂量静脉滴注异甘草酸镁注射液,在设计的时间点取静脉血,血药浓度采用高效液相色谱-紫外检测法测定。药动学参数采用3P87程序计算。结果单次静脉滴注异甘草酸镁200mg后的主要药动学参数:cmax(实测值)为(67.58±8.84)mg·L-1,t1/2α为(1.46±0.35)h,t1/2β(23.95±4.72)h,Vd为(2.921±0.382)L,CL为(0.:186±0.048)L·h-1,k10为(0.064±0.016)h-1,AUC0-1(以梯形法计算)为(1015.29±225.14)mg·h·L-1。结论本方法简单、快速,灵敏度和准确度较高,适合临床药动学研究。健康志愿者静脉滴注异甘草酸镁注射液后的体内过程呈线性特征,符合一级消除的二房室模型,从而指导临床合理用药。OBJECTIVE: To study the pharmacokinetics of intravenous magnesium isoglycyrrhizinate injection in healthy volunteers. METHODS: A single dose of 200 mg magnesium isoglycyrrhizinate was administered to 10 healthy volunteers by infusion. The concentration of magnesium isoglycyrrhizinate in plasma was measured by HPLC-UV method. The pharmacokinetic parameters of magnesium isoglycyrrhizinate injection were calculated by program 3P87. RESULTS: The main pharmacokinetic parameters of intravenous magnesium isoglycyrrhizinate were as follows: Cmax(67.58 ± 8.84)mg&middotL-1, t 1/2α(1.46 ± 0.35)h, t1/2β(23.95 ± 4.72)h, Vd(2.921 ± 0.382)L, CL(0.186 ± 0.048)L&middoth-1, k10(0.064 ± 0.016)h -1, AUC0∼t(1 015.29 ± 225.14) mgL-1, respectively. CONCLUSION: The pharmacokinetical properties of magnesium isoglycyrrhizinate in healthy volunteers was studied successfully after iv infusion. The method was found to be simple, accurate, stable and sensitive in clinical pharmacokinetics study. The concentration-time plot was fit to a two-compartment open model with first-order output.

关 键 词：高效液相色谱法 异甘草酸镁 药动学 

分 类 号：R969[医药卫生—药理学]