吡哌酸片溶出度光纤传感实时分析研究  

Study on dissolution of pipemidic acid tablets by fiber optic chemical sensor dissolution test system

作　　者：李莉[1] 陈坚[1] 李新霞[1] 张力[1] 邹华 

机构地区：[1]新疆医科大学药学院,新疆乌鲁木齐830054 [2]新疆富科思生物技术发展有限公司,新疆乌鲁木齐830054

出　　处：《中国药学杂志》2005年第10期786-788,共3页Chinese Pharmaceutical Journal

基　　金：新疆自治区高技术发展计划资助项目(200311110)新疆自治区中小企业创新基金资助(CXJ2002-10)

摘　　要：目的建立吡哌酸片剂溶出度的光纤传感实时检测方法。方法采用转篮法,转速100r·min-1,以稀盐酸(24→1000)为溶出介质,用光纤化学传感药物溶出度实时分析系统在320nm处检测紫外吸收。同时用药典规定方法检测溶出浓度,以作相互对照。结果在50.5-249μg·mL-1内,吸光度与吡哌酸片的浓度成线性关系,平均回收率为100.4%。光纤传感实时检测方法所得结果与药典方法结果无显著性差异(P>0.05)。结论所建立的吡哌酸片剂溶出度的光纤传感实时检测方法可行,在位在线、连续定量地反映了药物体外溶出特性。OBJECTIVE: To develop a fiber optic chemical sensor dissolution test system (FOCSDT) for determining the dissolution of pipemidic acid tablets. METHODS: The drug dissolution concentration was detected using the FOCSDT system, and the detection wavelength was at 320 nm. RESULTS: A good linearity was obtained over the range of 50.5-249 μg&middotmL-1. The average recovery rate was 100.4% (n = 6). The results obtained from the FOCSDT were no significantly different from the methods published in Chinese Pharmacopeia (2000) (P > 0.05). CONCLUSION: The new method established for the dissolution test of pipemidic acid tablets is feasible. As a procession analysis, FOCSDT system showed the real dissolution of drug and provided the total information.

关 键 词：光纤传感 吡哌酸 药物溶出度 

分 类 号：R927[医药卫生—药学]