材料表面处理对心内式血泵的生物相容性改善  

Improvement of Endocardiac Blood Pump Biocompatibility by Material Surface Treating

作　　者：陈新[1] 云中[2] 谭建平[2] 

机构地区：[1]株洲工学院包装与印刷学院,湖南株洲412008 [2]中南大学机电院,湖南长沙410018

出　　处：《表面技术》2005年第3期61-64,共4页Surface Technology

基　　金：国家自然科学基金(50275151);湖南省自然科学基金(02JJY2080)

摘　　要：　通过对血泵材料的血液相容性和生物组织相容性进行了分析,并对目前常用生物材料的表面处理技术进行了比较。由于心内式血泵置入心内的特殊部位,既要保证其血液相容性,又要保证组织相容性,可采取对材料表面生物药物活性处理来实现:与血液接触材料表面,可选择r 水蛭素处理,以提高材料的血液相容性;与各种生物组织材料接触的表面,可选择纤连蛋白处理,使材料表面内皮化,以提高材料的组织相容性。By analysis of blood compatibility and tissue compatibility of blood pump material, a comparison was given to the surface treating technology of the current commonly-used biomaterial. Owing to the particular position of micro-axial blood pump placed in heart, the active treating of bio-medicament on the material surface is used to ensure its blood and its tissue compatible. That is, r-hirudin treating is used on material interface with the blood to improve the blood compatibility; and fibronectin treating is used on the interface with various bio-tissue materials to endothelialize the surface of material and to improve its tissue compatibility.

关 键 词：血泵材料 表面处理 血液相容性 组织相容性 

分 类 号：R318.08[医药卫生—生物医学工程]