3种药物治疗抑郁症的成本-效果分析  

Cost-effectiveness Analysis in Treatment of Depression with Three Drugs

作　　者：黄建敏[1] 牛庆生[1] 

机构地区：[1]广东省珠海市人民医院药剂科,519000

出　　处：《医药导报》2005年第7期636-637,共2页Herald of Medicine

摘　　要：目的评价3种不同药物治疗抑郁症的经济效果.方法对98例抑郁症患者随机分组,分别用3种不同的药物治疗,A组33例给予氟西汀20 mg·d-1,B组33例给予文拉法辛50～200 mg·d-1,C组32例给予阿米替林50～200 mg·d-1,3组均为口服给药,疗程8周.运用药物经济学成本-效果分析方法比较.结果 A、B、C组的显效率分别为75.76%,87.88%,75.00%. B组方案成本-效果比较低,显效率较高.结论应用文拉法辛治疗抑郁症为较佳方案.Objective To evaluate the cost-effectiveness in the treatment of depression with three different drugs. Methods Ninety eight depression patients were randomly divided into three groups.Group A (33 cases) fluoxetine 20 mg·d -1 , group B(33 cases) venlafaxine 50-200 mg·d -1 , and group C (32 cases) amitriptyline 50-200 mg·d -1 . All the drugs were administrated orally for 8 weeks. Results The effective rates of group A,B and C were 75.76%,87.88%and 75.00%, respectively. Group B had a lower cost-effectiveness ratio and higher effective rate. Conclusion Venlafaxineis superior than the other two drugs in the treatment of depression.

关 键 词：氟西汀 文拉法辛 阿米替林 抑郁症 成本-效果分析 

分 类 号：R971.43[医药卫生—药品] F407.7[医药卫生—药学]