应用罂粟碱和利多卡因预防与治疗微小血管吻合术后的血管痉挛  

Prevention and curation on blood vessels spasm after small vascular (anastomosis) by using papaverine and lidocain

作　　者：王培吉[1] 王雅坤[2] 

机构地区：[1]解放军第208医院骨科,吉林长春130062 [2]吉林大学第一临床医院眼科,吉林长春130021

出　　处：《延边大学医学学报》2005年第2期121-123,共3页Journal of Medical Science Yanbian University

摘　　要：[目的]探讨显微外科手术后给微小血管吻合口处持续局部应用罂粟碱和利多卡因对血管痉挛的预防和治疗作用.[方法]应用弹力输液泵将罂粟碱和利多卡因直接缓慢持续注入家兔股动脉吻合口周围,每日3～4次,术后6h,1,3,5,7d观察局部组织变化,根据股动脉直径的变化及血栓形成情况了解股动脉痉挛的发生情况.[结果]经冰块冷敷和烟熏处理30min后,A组(局部给药)、B组(肌肉注射)家兔股动脉直径变化较小,C组(局部生理盐水)家兔股动脉直径较正常缩小30%～40%,呈痉挛状态,A组和B组与C组比较均有显著性差异;A组的20条股动脉经血管吻合术后均通畅,B组有19条血管通畅,而C组则有16条血管通畅.[结论]利用PCA泵在微小血管吻合口周围给予罂粟碱和利多卡因可有效地预防与治疗血管痉挛.OBJECTIVETo study the effects of papaverine and lidocain for preventing blood vessel (spasm) (after) Blood vessel spasm.METHODSThe papaverine and lidocain were directly concentrated on the area of (anastomosis) with femoral arterias of rabbits through plastic infusion pump, and observed. In each group, ice cubes compress and smoke were used 3～4times per day. Their morphology and histology were observed at 6h,1,3,5,7d after operation.RESULTSThere were little change of femoral artery inside diameter in group A ((continual) local medicine) and group B (muscular injection). However, the diameter decreased significantly in group C (saline),and it was 30%～40%, and femoral artery was spasticity. In addition, blood vessel smooth rate was 20 cases in group A, and 19 cases in group B, however 16 cases in group C.CONCLUSIONTo pour (papaverine) and lidocain into the vascular stomaby PCA pump for prevention and therapy of vascular spasm could obtain the satisfactory effect.

关 键 词：痉挛 血管 吻合术 外科 血管舒张药 

分 类 号：R654.4[医药卫生—外科学]