老年SD大鼠的血液流变学与相关生化指标的研究  

Study on Hemorrheology and Relevant Serum Biochemistry Values in Old SD Rats

作　　者：吕建敏[1] 王德军[1] 寿旗扬[1] 林琳[1] 周卫民[1] 陈民利[1] 

机构地区：[1]浙江中医学院动物实验研究中心,杭州310053

出　　处：《实验动物科学与管理》2005年第2期1-3,共3页Laboratory Animal Science & Administration

摘　　要：目的　了解老年大鼠的血液学特性,测定老年与成年SD大鼠的血液流变学各项参数和血清超氧化物歧化酶(SOD)、丙二醛(MDA)、甘油三酯(TG)、总胆固醇(TC)、葡萄糖(GLU)等五项生化指标,并比较二者差异。方法　选用2 0只老年SD大鼠(SPF级,1 5月龄)和2 0只成年SD大鼠(SPF级,3月龄) ,用LBY -N6B型全自动模块式血液流变仪进行血液流变学的分析,用半自动生化仪测定各项生化指标。结果　老年SD大鼠的全血液粘度、全血还原粘度、红细胞聚集指数、红细胞电泳指数、总胆固醇(TC)和丙二醛(MDA)等指标显著高于成年大鼠(P <0 . 0 5 ,P <0 . 0 1 )。结论　老年SD大鼠的血液流变学变化规律和一些与衰老相关的生化指标与人类存在一定的相似性。Objective To learn about the biological characteristics of the old SD rats, hemorrheological parameters and serum biochemistry values such as SOD, MDA, TG, TC and GLU of the old and the adult SD rats and the differences between the old and the adult SD rats were compared. Method Twenty old SD rats (SPF, 15 months) and 20 adult SD rats (SPF, 3months) were used in this experiment, hemorrheological parameters and serum biochemistry, values were determined using the instruments of hemorrheology and the semi-automatic biochemistry analyzer respectively. Results The whole blood viscosity, the whole blood deoxidized viscosity, the aggregation index of RBC, the electrophoresis index of RBC, the TC and the MDA of the old SD rat were significantly higher than those of the younsers(%P%<0.05, %P%<0.01).Conclusion The indexes showed above are related to the age. They are all increased when the rat get old, which demonstrate the similar trend to human being.

关 键 词：老年SD大鼠 血液流变学 生化指标 

分 类 号：R446.12[医药卫生—诊断学]