环境铅污染及其毒性的研究进展  

Environmental Lead Pollution and Progress in the Study of Lead Toxicity

作　　者：徐进[1] 徐立红[1] 

机构地区：[1]浙江大学医学院生物化学与分子生物学教研室,浙江杭州310031

出　　处：《环境与职业医学》2005年第3期271-274,共4页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金重点项目(编号:20137010)国家自然科学基金项目(编号:30270257)

摘　　要：铅是一种常见的环境污染物,给人类健康带来了巨大的损害。人类对铅的毒性研究已有上千年的历史,但近些年来伴随着现代生物技术的飞速发展,铅的毒性机制得到了深入的研究,同时也发现了一系列的敏感标志物。本文从铅的致癌性、认知能力和行为功能改变、遗传物质损伤、诱导细胞凋亡等方面进行综述。Lead is a ubiquitous environmental pollutant, which causes great damage to the human health. We,human beings,have studied the toxicity of lead for thousands of years,and with the help of modern biotechnology, mechanisms of lead toxicity and sensitive biomarkers are found little by little.This review was to examine new developments in understanding of the toxicity of lead. It has focused especially on lead-induced carcinogenesis, cognition and behavior dysfunction,genotoxicity and apoptosis.

关 键 词：铅 污染 毒性 

分 类 号：R114[医药卫生—卫生毒理学]