敏康片对变应性鼻炎大鼠一般情况及血浆组胺的影响  

Effects of "Minkang Tablet" on the General Conditions and Plasma Histamine in Rats with Allergic Rhinitis

作　　者：郑湘瑞[1] 姚忆[1] 贯剑[1] 倪红梅[1] 吴艳萍[1] 何裕民[1] 

机构地区：[1]上海中医药大学,上海201203

出　　处：《上海中医药大学学报》2005年第2期45-47,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30100234)

摘　　要：目的探讨中药敏康片对变应性鼻炎大鼠一般情况和血浆组胺的影响。方法除正常组外,其余大鼠用卵清蛋白造成变应性鼻炎模型,随机分为模型组、西药对照组(酮替芬组)、中药对照组(辛芩冲剂组)、敏康片小剂量组、敏康片大剂量组;用药1周后观察大鼠一般情况及鼻黏膜肥大细胞数、脱颗粒细胞数、血浆组胺的变化。结果造模组有明显的喷嚏、流鼻涕和搔鼻等症状,鼻黏膜肥大细胞数、脱颗粒细胞数、血浆组胺明显升高。各治疗组均明显改善,其中敏康片大剂量组在大鼠的一般情况变化和体征方面与辛芩冲剂组疗效相当,敏康片小剂量组在降低肥大细胞数、脱颗粒细胞数及血浆组胺方面较明显,但与大剂量组和辛芩冲剂组之间没有统计学意义。结论敏康片能够改善变应性鼻炎大鼠的一般症状和体征,其治疗作用可能与减少鼻黏膜肥大细胞数及脱颗粒细胞数,降低血浆组织胺含量有关。Objective To study the effects of 'Minkang Tablets(MKT)' on the general condition and plasma histamine in the rat with allergic rhinitis(AR). Methods 50 Wistar rats were sensitized by Ovalbumin as animal model of AR and randomly divided into 5 groups: model group, Ketotifen Fumarate group, XinQin Granules group, low-dose Minkang Tablet group, and high-dose Minkang tablet group,another 10 healthy rats in normal group. The general condition, mass cell and degranulation mass cell in nasal mucosa as well as the contents of histamine were determined and compared among all the groups after one week. Results In model group, the symptoms in model group such as sneezing, running nose and scratching nose are obvious, with obviously increased mass cell and degranulation cell in nasal mucosa plasma histamine; high-dose Minkang Tablet group and XinQin Granules group were similar in improving the general condition and symptoms; but in the low-dose Minkang Tablet group, the numbers of mast cell and degranulation cell as well as the content of histamine decreased, with no difference compared to the former groups. Conclusion Minkang Tablet can improve the general condition and symptoms of AR possibly by reducing the numbers of mast cell and degranulation, and the content of plasma histamine.

关 键 词：敏康片 变应性鼻炎 肥大细胞 组胺 

分 类 号：R285.5[医药卫生—中药学] R765.213[医药卫生—中医学]