6-氟-2-嘧啶氧基-N-取代苯基苄胺类化合物的合成及其除草活性  

Synthesis and Herbicidal Activity of 6-Fluoro-2-pyrimindinyloxy-N-substituted Phenyl Benzylamine Derivatives

作　　者：龚启孙[1] 彭伟立 沈德隆[1] 陈杰 

机构地区：[1]浙江工业大学农药研究所,浙江杭州310014 [2]国家南方农药创制中心浙江基地,浙江杭州310023

出　　处：《农药学学报》2005年第2期176-180,共5页Chinese Journal of Pesticide Science

基　　金：国家"十五"科技攻关项目(2004BA308A22);浙江省科技厅重大国际合作项目(021106401).

摘　　要：从起始原料引入氟原子,分别经亚胺化、硼氢化钠还原、嘧啶氧化,及嘧啶氧化、溴化、胺化两条路线合成了28个新型的6-氟-2-嘧啶氧基-N-取代苯基苄胺类化合物;同时测试了该类化合物在温室中对稗草Echinochloa crusgalli等3种禾本科杂草和反枝苋Amaranthus retroflexus等3种阔叶杂草芽前、芽后的抑制率,结果表明,有12种目标化合物在有效剂量75g/hm2下其抑制率超过80%。Using fluorine-containing compounds as starting material, 28 novel 6-fluoro-2- (pyrimindinyloxy-)N-substituted phenyl benzylamine derivatives were synthesized by two different routes, which are imination, deoxidation, pyrimidinyloxylation and pyrimidinyloxylation, (bromination) and (amination.) Preliminary bioassay indicates that 12 compounds showed excellent (herbicidal) activities, the inhibition rate of most compounds was above 80% at 75 g a.i./hm^2 against both pre- and post-emergence of Echinochloa crusgalli, Amaranthus retroflexus, etc.

关 键 词：6-氟-2-嘧啶氧基苄胺 乙酰乳酸合成酶抑制剂 合成 除草活性 

分 类 号：O621.29[理学—有机化学]