LEP,IGF-1和TNFα测定对乳腺癌患者的临床意义  

Clinical Significance of Detection of Serum Leptin,Insulin-Like Growth Factor-1 and Tumor Necrosis Factor α in Breast Cancer Patients

作　　者：王秀明[1] 郝良华[2] 孙东明 

机构地区：[1]潍坊市妇幼保健院检验科,山东潍坊261011 [2]潍坊市妇幼保健院妇科 [3]潍坊市市立医院

出　　处：《潍坊医学院学报》2005年第3期188-189,共2页Acta Academiae Medicinae Weifang

摘　　要：目的乳腺癌患者血清瘦素(LEP)、胰岛素样生长因子-1(IGF-1)、肿瘤坏死因子α(TNFα)测定的临床意义。方法用放射免疫分析法(RIA)和免疫放射分析法(IRMA)测定良性、恶性乳腺病变患者和正常对照者血清LEP,IGF-1和TNFα的浓度。结果LEP,IGF-1和TNFα的浓度在乳腺癌患者与正常对照者之间差异均有显著性。结论LEP,IGF-1和TNFα浓度测定有助于乳腺癌的诊断、治疗和研究。Objective To research the clinical significance in the detection of serum leptin(LEP),insulin-like growth factor-1(IGF-1) and tumor necrosis factor α(TNFα) in breast cancer patients.Methods Using RIA and IRMA method to detect the serum concentrations of LEP,IGF-1,TNFα in breast cancer patient,breast benign lesion patients and normal controls.Results Serum concentrations of LEP,IGF-1,TNFα in breast cancer patient were obviously different from that of normal control group.Conclusion Detection of the serum concentrations of LEP,IGF-1,TNFα is useful for diagnosis,treating and research of breast cancer.

关 键 词：瘦素 胰岛素样生长因子-1 肿瘤坏死因子Α 乳腺癌 

分 类 号：R655.8[医药卫生—外科学]